Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors
Joint Authors
Martín-Márquez, Beatriz Teresita
Corona-Sanchez, Esther Guadalupe
Gómez-Bañuelos, Eduardo
Navarro-Hernandez, Rosa Elena
Martínez-García, Erika Aurora
Figueroa-Sánchez, Mauricio
Macias-Reyes, Héctor
Nuñez-Atahualpa, María Alejandra
Andrade-Garduño, Javier
Gonzalez-Lopez, Laura
Vázquez-Del Mercado, Mónica
Nuñez-Atahualpa, Lourdes
Gamez-Nava, Jorge Ivan
Rocha-Muñoz, Alberto Daniel
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The main cause of death in rheumatoid arthritis (RA) is cardiovascular events.
We evaluated the relationship of anticyclic citrullinated peptide (anti-CCP) antibody levels with increased carotid intima-media thickness (cIMT) in RA patients.
Methods.
Forty-five anti-CCP positive and 37 anti-CCP negative RA patients, and 62 healthy controls (HC) were studied.
All groups were assessed for atherogenic index of plasma (AIP) and cIMT.
Anti-CCP, C-reactive protein (CRP), and levels of tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6) were measured by enzyme-linked immunosorbent assay (ELISA).
Results.
The anti-CCP positive RA patients showed increased cIMT compared to HC and anti-CCP negative (P<0.001).
Anti-CCP positive versus anti-CCP negative RA patients, had increased AIP, TNFα and IL-6 (P<0.01), and lower levels of high density lipoprotein cholesterol (HDL-c) (P=0.02).
The cIMT correlated with levels of anti-CCP (r=0.513, P=0.001), CRP (r=0.799, P<0.001), TNFα (r=0.642, P=0.001), and IL-6 (r=0.751, P<0.001).
In multiple regression analysis, cIMT was associated with CRP (P<0.001) and anti-CCP levels (P=0.03).
Conclusions.
Levels of anti-CCP and CRP are associated with increased cIMT and cardiovascular risk supporting a clinical role of the measurement of cIMT in RA in predicting and preventing cardiovascular events.
American Psychological Association (APA)
Vázquez-Del Mercado, Mónica& Nuñez-Atahualpa, Lourdes& Figueroa-Sánchez, Mauricio& Gómez-Bañuelos, Eduardo& Rocha-Muñoz, Alberto Daniel& Martín-Márquez, Beatriz Teresita…[et al.]. 2015. Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055118
Modern Language Association (MLA)
Vázquez-Del Mercado, Mónica…[et al.]. Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055118
American Medical Association (AMA)
Vázquez-Del Mercado, Mónica& Nuñez-Atahualpa, Lourdes& Figueroa-Sánchez, Mauricio& Gómez-Bañuelos, Eduardo& Rocha-Muñoz, Alberto Daniel& Martín-Márquez, Beatriz Teresita…[et al.]. Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055118