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Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment
المؤلفون المشاركون
Kageyama, Susumu
Hanada, Eiki
Ii, Hiromi
Tomita, Keiji
Yoshiki, Tatsuhiro
Kawauchi, Akihiro
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-03
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Gamma-glutamylcyclotransferase (GGCT) is one of the major enzymes involved in glutathione metabolism.
However, its gene locus was unknown for many years.
Recently, the gene for GGCT was found to be identical to C7orf24, which is registered as a hypothetical protein.
Orthologs have been found in bacteria, plants, and nematodes as well as higher organisms, and the GGCT gene is highly preserved among a wide range of species.
GGCT (C7orf24) was also reported as an upregulated protein in various cancers.
Although the function of GGCT in cancer cells has not been determined, the following important activities have been reported: (1) high expression in various cancer tissues and cancer cell lines, (2) low expression in normal tissues, (3) inhibition of cancer cell proliferation via anti-GGCT RNAi, (4) inhibition of cancer cell invasion and migration via anti-GGCT RNAi, (5) an epigenetic transcriptional regulation in cancer cells, and (6) an antitumor effect in cancer-bearing xenograft mice.
Therefore, GGCT is promising as a diagnostic marker and a therapeutic target for various cancers.
This review summarizes these interesting findings.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kageyama, Susumu& Hanada, Eiki& Ii, Hiromi& Tomita, Keiji& Yoshiki, Tatsuhiro& Kawauchi, Akihiro. 2015. Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1055129
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kageyama, Susumu…[et al.]. Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1055129
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kageyama, Susumu& Hanada, Eiki& Ii, Hiromi& Tomita, Keiji& Yoshiki, Tatsuhiro& Kawauchi, Akihiro. Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1055129
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055129
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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