Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment
Joint Authors
Kageyama, Susumu
Hanada, Eiki
Ii, Hiromi
Tomita, Keiji
Yoshiki, Tatsuhiro
Kawauchi, Akihiro
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Gamma-glutamylcyclotransferase (GGCT) is one of the major enzymes involved in glutathione metabolism.
However, its gene locus was unknown for many years.
Recently, the gene for GGCT was found to be identical to C7orf24, which is registered as a hypothetical protein.
Orthologs have been found in bacteria, plants, and nematodes as well as higher organisms, and the GGCT gene is highly preserved among a wide range of species.
GGCT (C7orf24) was also reported as an upregulated protein in various cancers.
Although the function of GGCT in cancer cells has not been determined, the following important activities have been reported: (1) high expression in various cancer tissues and cancer cell lines, (2) low expression in normal tissues, (3) inhibition of cancer cell proliferation via anti-GGCT RNAi, (4) inhibition of cancer cell invasion and migration via anti-GGCT RNAi, (5) an epigenetic transcriptional regulation in cancer cells, and (6) an antitumor effect in cancer-bearing xenograft mice.
Therefore, GGCT is promising as a diagnostic marker and a therapeutic target for various cancers.
This review summarizes these interesting findings.
American Psychological Association (APA)
Kageyama, Susumu& Hanada, Eiki& Ii, Hiromi& Tomita, Keiji& Yoshiki, Tatsuhiro& Kawauchi, Akihiro. 2015. Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1055129
Modern Language Association (MLA)
Kageyama, Susumu…[et al.]. Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1055129
American Medical Association (AMA)
Kageyama, Susumu& Hanada, Eiki& Ii, Hiromi& Tomita, Keiji& Yoshiki, Tatsuhiro& Kawauchi, Akihiro. Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1055129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055129