Applying NGS Data to Find Evolutionary Network Biomarkers from the Early and Late Stages of Hepatocellular Carcinoma
المؤلفون المشاركون
Chen, Bor-Sen
Chang, Tzu-Hao
Wong, Yung-Hao
Wu, Chia-Chou
Lin, Chih-Lung
Chen, Ting-Shou
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-27، 27ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-20
دولة النشر
مصر
عدد الصفحات
27
التخصصات الرئيسية
الملخص EN
Hepatocellular carcinoma (HCC) is a major liver tumor (~80%), besides hepatoblastomas, angiosarcomas, and cholangiocarcinomas.
In this study, we used a systems biology approach to construct protein-protein interaction networks (PPINs) for early-stage and late-stage liver cancer.
By comparing the networks of these two stages, we found that the two networks showed some common mechanisms and some significantly different mechanisms.
To obtain differential network structures between cancer and noncancer PPINs, we constructed cancer PPIN and noncancer PPIN network structures for the two stages of liver cancer by systems biology method using NGS data from cancer cells and adjacent noncancer cells.
Using carcinogenesis relevance values (CRVs), we identified 43 and 80 significant proteins and their PPINs (network markers) for early-stage and late-stage liver cancer.
To investigate the evolution of network biomarkers in the carcinogenesis process, a primary pathway analysis showed that common pathways of the early and late stages were those related to ordinary cancer mechanisms.
A pathway specific to the early stage was the mismatch repair pathway, while pathways specific to the late stage were the spliceosome pathway, lysine degradation pathway, and progesterone-mediated oocyte maturation pathway.
This study provides a new direction for cancer-targeted therapies at different stages.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wong, Yung-Hao& Wu, Chia-Chou& Lin, Chih-Lung& Chen, Ting-Shou& Chang, Tzu-Hao& Chen, Bor-Sen. 2015. Applying NGS Data to Find Evolutionary Network Biomarkers from the Early and Late Stages of Hepatocellular Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-27.
https://search.emarefa.net/detail/BIM-1055296
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wong, Yung-Hao…[et al.]. Applying NGS Data to Find Evolutionary Network Biomarkers from the Early and Late Stages of Hepatocellular Carcinoma. BioMed Research International No. 2015 (2015), pp.1-27.
https://search.emarefa.net/detail/BIM-1055296
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wong, Yung-Hao& Wu, Chia-Chou& Lin, Chih-Lung& Chen, Ting-Shou& Chang, Tzu-Hao& Chen, Bor-Sen. Applying NGS Data to Find Evolutionary Network Biomarkers from the Early and Late Stages of Hepatocellular Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-27.
https://search.emarefa.net/detail/BIM-1055296
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055296
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر