Applying NGS Data to Find Evolutionary Network Biomarkers from the Early and Late Stages of Hepatocellular Carcinoma
Joint Authors
Chen, Bor-Sen
Chang, Tzu-Hao
Wong, Yung-Hao
Wu, Chia-Chou
Lin, Chih-Lung
Chen, Ting-Shou
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-20
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is a major liver tumor (~80%), besides hepatoblastomas, angiosarcomas, and cholangiocarcinomas.
In this study, we used a systems biology approach to construct protein-protein interaction networks (PPINs) for early-stage and late-stage liver cancer.
By comparing the networks of these two stages, we found that the two networks showed some common mechanisms and some significantly different mechanisms.
To obtain differential network structures between cancer and noncancer PPINs, we constructed cancer PPIN and noncancer PPIN network structures for the two stages of liver cancer by systems biology method using NGS data from cancer cells and adjacent noncancer cells.
Using carcinogenesis relevance values (CRVs), we identified 43 and 80 significant proteins and their PPINs (network markers) for early-stage and late-stage liver cancer.
To investigate the evolution of network biomarkers in the carcinogenesis process, a primary pathway analysis showed that common pathways of the early and late stages were those related to ordinary cancer mechanisms.
A pathway specific to the early stage was the mismatch repair pathway, while pathways specific to the late stage were the spliceosome pathway, lysine degradation pathway, and progesterone-mediated oocyte maturation pathway.
This study provides a new direction for cancer-targeted therapies at different stages.
American Psychological Association (APA)
Wong, Yung-Hao& Wu, Chia-Chou& Lin, Chih-Lung& Chen, Ting-Shou& Chang, Tzu-Hao& Chen, Bor-Sen. 2015. Applying NGS Data to Find Evolutionary Network Biomarkers from the Early and Late Stages of Hepatocellular Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-27.
https://search.emarefa.net/detail/BIM-1055296
Modern Language Association (MLA)
Wong, Yung-Hao…[et al.]. Applying NGS Data to Find Evolutionary Network Biomarkers from the Early and Late Stages of Hepatocellular Carcinoma. BioMed Research International No. 2015 (2015), pp.1-27.
https://search.emarefa.net/detail/BIM-1055296
American Medical Association (AMA)
Wong, Yung-Hao& Wu, Chia-Chou& Lin, Chih-Lung& Chen, Ting-Shou& Chang, Tzu-Hao& Chen, Bor-Sen. Applying NGS Data to Find Evolutionary Network Biomarkers from the Early and Late Stages of Hepatocellular Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-27.
https://search.emarefa.net/detail/BIM-1055296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055296