Stem Cell Therapy for Corneal Epithelium Regeneration following Good Manufacturing and Clinical Procedures
المؤلفون المشاركون
Fernández, Itziar
Ramírez, Beatriz E.
Sánchez, Ana
Herreras, José M.
García-Sancho, Javier
Nieto-Miguel, Teresa
Calonge, Margarita
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-16
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate outcomes of cultivated limbal epithelial transplantation (CLET) for management of ocular surface failure due to limbal stem cell deficiency (LSCD).
Design.
Prospective, noncomparative, interventional case series and extensive comparison with recent similar studies.
Participants.
Twenty eyes with LSCD underwent CLET (11 autologous; 9 allogeneic) and were followed up for 3 years.
Etiologies were divided into 3 prognostic categories: Group 1, chemical injuries (7 eyes); Group 2, immune-based inflammation (4 eyes); and Group 3, noninflammatory diseases (9 eyes).
Intervention.
Autologous and allogeneic limbal epithelial cells were cultivated on amniotic membranes and transplanted.
Evaluations were based on clinical parameters, survival analysis, and in vivo confocal microscopy (IVCM).
European Union Tissues/Cells Directive and good manufacturing procedures were followed.
Main Outcome Measures.
Improved clinical parameters, absence of epithelial defects, and improved central corneal epithelial phenotype.
Results.
Success rate was 80% at 1-2 years and 75% at 3 years.
Autografts and allografts had similar survival.
Success rate was significantly lower in prognostic Group 1 (42.9%) than in Groups 2-3 (100% each).
All clinical parameters improved substantially.
By IVCM, 80% of cases improved in epithelial status.
Conclusions.
CLET improved corneal epithelium quality, with subsequent improvement in symptoms, quality of life, and vision.
These results confirm that CLET is a valid therapy for ocular surface failure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ramírez, Beatriz E.& Sánchez, Ana& Herreras, José M.& Fernández, Itziar& García-Sancho, Javier& Nieto-Miguel, Teresa…[et al.]. 2015. Stem Cell Therapy for Corneal Epithelium Regeneration following Good Manufacturing and Clinical Procedures. BioMed Research International،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1055370
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ramírez, Beatriz E.…[et al.]. Stem Cell Therapy for Corneal Epithelium Regeneration following Good Manufacturing and Clinical Procedures. BioMed Research International No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1055370
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ramírez, Beatriz E.& Sánchez, Ana& Herreras, José M.& Fernández, Itziar& García-Sancho, Javier& Nieto-Miguel, Teresa…[et al.]. Stem Cell Therapy for Corneal Epithelium Regeneration following Good Manufacturing and Clinical Procedures. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1055370
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055370
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر