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Antiresistin RNA Oligonucleotide Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Attenuating Proinflammatory Cytokines
المؤلفون المشاركون
Xiao, Linda
Lao, Weiguo
Kim, Jane J. Y.
Tan, Yi
Jin, Xing Liang
Qu, Xianqin
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The aim of this study was to determine whether inhibition of resistin by a synthetic antiresistin RNA (oligonucleotide) oligo ameliorates metabolic and histological abnormalities in nonalcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD) in mice.
The antiresistin RNA oligo and a scrambled control oligo (25 mg/kg of body weight) were i.p.
injected to HFD mice.
Serum metabolic parameters and hepatic enzymes were measured after 4-week treatment.
The treatment significantly reduced epididymal fat and attenuated the elevated serum resistin, cholesterol, triglycerides, glucose, and insulin with an improved glucose tolerance test.
Antiresistin RNA oligo also normalized serum AST and ALT levels with improved pathohistology of NAFLD.
Immunoblotting and qRT-PCR revealed that decreased protein and mRNA expression of resistin in fat and liver tissues of the treated mice were associated with reduction of adipose TNF-α and IL-6 expression and secretion into circulation.
mRNA and protein expression of hepatic phosphoenolpyruvate carboxykinase (PEPCK) and sterol regulatory element-binding protein-1c (SREBP-1c) were also significantly decreased in the treated mice.
Our results suggest that resistin may exacerbate NAFLD in metabolic syndrome through upregulating inflammatory cytokines and hepatic PEPCK and SREBP-1c.
Antiresistin RNA oligo ameliorated metabolic abnormalities and histopathology of NAFLD through attenuating proinflammatory cytokines.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tan, Yi& Jin, Xing Liang& Lao, Weiguo& Kim, Jane J. Y.& Xiao, Linda& Qu, Xianqin. 2015. Antiresistin RNA Oligonucleotide Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Attenuating Proinflammatory Cytokines. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055397
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tan, Yi…[et al.]. Antiresistin RNA Oligonucleotide Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Attenuating Proinflammatory Cytokines. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055397
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tan, Yi& Jin, Xing Liang& Lao, Weiguo& Kim, Jane J. Y.& Xiao, Linda& Qu, Xianqin. Antiresistin RNA Oligonucleotide Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Attenuating Proinflammatory Cytokines. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055397
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055397
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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