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Antiresistin RNA Oligonucleotide Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Attenuating Proinflammatory Cytokines
Joint Authors
Xiao, Linda
Lao, Weiguo
Kim, Jane J. Y.
Tan, Yi
Jin, Xing Liang
Qu, Xianqin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The aim of this study was to determine whether inhibition of resistin by a synthetic antiresistin RNA (oligonucleotide) oligo ameliorates metabolic and histological abnormalities in nonalcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD) in mice.
The antiresistin RNA oligo and a scrambled control oligo (25 mg/kg of body weight) were i.p.
injected to HFD mice.
Serum metabolic parameters and hepatic enzymes were measured after 4-week treatment.
The treatment significantly reduced epididymal fat and attenuated the elevated serum resistin, cholesterol, triglycerides, glucose, and insulin with an improved glucose tolerance test.
Antiresistin RNA oligo also normalized serum AST and ALT levels with improved pathohistology of NAFLD.
Immunoblotting and qRT-PCR revealed that decreased protein and mRNA expression of resistin in fat and liver tissues of the treated mice were associated with reduction of adipose TNF-α and IL-6 expression and secretion into circulation.
mRNA and protein expression of hepatic phosphoenolpyruvate carboxykinase (PEPCK) and sterol regulatory element-binding protein-1c (SREBP-1c) were also significantly decreased in the treated mice.
Our results suggest that resistin may exacerbate NAFLD in metabolic syndrome through upregulating inflammatory cytokines and hepatic PEPCK and SREBP-1c.
Antiresistin RNA oligo ameliorated metabolic abnormalities and histopathology of NAFLD through attenuating proinflammatory cytokines.
American Psychological Association (APA)
Tan, Yi& Jin, Xing Liang& Lao, Weiguo& Kim, Jane J. Y.& Xiao, Linda& Qu, Xianqin. 2015. Antiresistin RNA Oligonucleotide Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Attenuating Proinflammatory Cytokines. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055397
Modern Language Association (MLA)
Tan, Yi…[et al.]. Antiresistin RNA Oligonucleotide Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Attenuating Proinflammatory Cytokines. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055397
American Medical Association (AMA)
Tan, Yi& Jin, Xing Liang& Lao, Weiguo& Kim, Jane J. Y.& Xiao, Linda& Qu, Xianqin. Antiresistin RNA Oligonucleotide Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Attenuating Proinflammatory Cytokines. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055397