Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn’s Disease
المؤلفون المشاركون
Urabe, Shigetoshi
Ishida, Tetsuya
Maeda, Kazumi
Inamine, Tatsuo
Kondo, Shinji
Higuchi, Norihide
Sato, Kayoko
Yajima, Hiroyuki
Machida, Haruhisa
Fukuda, Yasuhiro
Tsukamoto, Kazuhiro
Takeshima, Fuminao
Nakao, Kazuhiko
Uehara, Ryohei
Chen, Chun Chuan
Isomoto, Hajime
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
We aimed to identify certain genes related to response to infliximab (IFX) and biomarkers to predict the IFX effect for Japanese Crohn’s disease (CD) patients by performing an association study of single nucleotide polymorphisms (SNPs) in candidate genes in the interleukin- (IL-) 17 signaling pathway with response to IFX after 1 year of treatment.
Methods.
A total of 103 patients were divided into two groups, responders and nonresponders.
Twenty-eight tag SNPs in 5 genes were genotyped.
The frequencies of alleles and genotypes of each SNP were compared between responders and nonresponders in three different inheritance models.
A genetic test was performed using a combination of the associated SNPs as biomarkers.
Results.
Multivariate logistic regression analysis indicated that the four variable factors, concomitant use of immunomodulators, penetrating disease, a G/G genotype of rs766748 in IL-17F, and a C/C or C/A genotype of rs1883136 in TRAF3IP2, independently contributed to response to IFX after 1 year of treatment.
Genetic test using the polymorphisms of these genes perfectly predicted the responder and nonresponder CD patients with both concomitant use of immunomodulators and penetrating disease.
Conclusion.
IL17F and TRAF3IP2 are one of IFX-related genes, useful as biomarkers of IFX response, and may be target molecules for new therapeutic drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Urabe, Shigetoshi& Isomoto, Hajime& Ishida, Tetsuya& Maeda, Kazumi& Inamine, Tatsuo& Kondo, Shinji…[et al.]. 2015. Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn’s Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055405
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Urabe, Shigetoshi…[et al.]. Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn’s Disease. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055405
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Urabe, Shigetoshi& Isomoto, Hajime& Ishida, Tetsuya& Maeda, Kazumi& Inamine, Tatsuo& Kondo, Shinji…[et al.]. Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn’s Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055405
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055405
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر