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Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn’s Disease
Joint Authors
Urabe, Shigetoshi
Ishida, Tetsuya
Maeda, Kazumi
Inamine, Tatsuo
Kondo, Shinji
Higuchi, Norihide
Sato, Kayoko
Yajima, Hiroyuki
Machida, Haruhisa
Fukuda, Yasuhiro
Tsukamoto, Kazuhiro
Takeshima, Fuminao
Nakao, Kazuhiko
Uehara, Ryohei
Chen, Chun Chuan
Isomoto, Hajime
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
We aimed to identify certain genes related to response to infliximab (IFX) and biomarkers to predict the IFX effect for Japanese Crohn’s disease (CD) patients by performing an association study of single nucleotide polymorphisms (SNPs) in candidate genes in the interleukin- (IL-) 17 signaling pathway with response to IFX after 1 year of treatment.
Methods.
A total of 103 patients were divided into two groups, responders and nonresponders.
Twenty-eight tag SNPs in 5 genes were genotyped.
The frequencies of alleles and genotypes of each SNP were compared between responders and nonresponders in three different inheritance models.
A genetic test was performed using a combination of the associated SNPs as biomarkers.
Results.
Multivariate logistic regression analysis indicated that the four variable factors, concomitant use of immunomodulators, penetrating disease, a G/G genotype of rs766748 in IL-17F, and a C/C or C/A genotype of rs1883136 in TRAF3IP2, independently contributed to response to IFX after 1 year of treatment.
Genetic test using the polymorphisms of these genes perfectly predicted the responder and nonresponder CD patients with both concomitant use of immunomodulators and penetrating disease.
Conclusion.
IL17F and TRAF3IP2 are one of IFX-related genes, useful as biomarkers of IFX response, and may be target molecules for new therapeutic drugs.
American Psychological Association (APA)
Urabe, Shigetoshi& Isomoto, Hajime& Ishida, Tetsuya& Maeda, Kazumi& Inamine, Tatsuo& Kondo, Shinji…[et al.]. 2015. Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn’s Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055405
Modern Language Association (MLA)
Urabe, Shigetoshi…[et al.]. Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn’s Disease. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055405
American Medical Association (AMA)
Urabe, Shigetoshi& Isomoto, Hajime& Ishida, Tetsuya& Maeda, Kazumi& Inamine, Tatsuo& Kondo, Shinji…[et al.]. Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn’s Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055405