Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma
المؤلفون المشاركون
Lu, Jianjun
Pan, You
Xia, Xin
Gu, Yong
Lei, Yiyan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The prognostic value of mTOR in ESCC is much controversial; this study aimed to determine the prognostic importance of mTOR and PTEN in patients with ESCC.
A total of 148 consecutive patients who underwent esophagectomy from 2010 to 2012 were included in this study, tested by western bolt and immunohistochemistry for mTOR and PTEN expression.
Correlation coefficient was calculated using Pearson’s correlation test.
The 3-year overall survival (OS) and disease-free survival (DFS) were calculated in relation to the two markers.
94 (63.5%) of 148 were mTOR high expression, and PTEN high expression was detected in 46 (31.1%) of the 148 patients with ESCC.
The Pearson correlation coefficient revealed a significant negative correlation in two proteins (correlation coefficient = −0.189, P < 0.005 ).
The 3-year OS and DFS time in the mTOR-high group was 23.9 and 18.4 months, respectively, and the time in the mTOR-low group was 33.9 months and 31.4 months, respectively.
The difference of survival rate between the two groups remained statistically significant.
mTOR-low or PTEN-high patients had better 3-year rates of OS and DFS than mTOR-high or PTEN-low group ( P < 0.001 by the log-rank test).
This study also found that mTOR was an independence prognostic factor by multivariate analysis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Jianjun& Pan, You& Xia, Xin& Gu, Yong& Lei, Yiyan. 2015. Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055407
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Jianjun…[et al.]. Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055407
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Jianjun& Pan, You& Xia, Xin& Gu, Yong& Lei, Yiyan. Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055407
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055407
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر