Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma
Joint Authors
Lu, Jianjun
Pan, You
Xia, Xin
Gu, Yong
Lei, Yiyan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The prognostic value of mTOR in ESCC is much controversial; this study aimed to determine the prognostic importance of mTOR and PTEN in patients with ESCC.
A total of 148 consecutive patients who underwent esophagectomy from 2010 to 2012 were included in this study, tested by western bolt and immunohistochemistry for mTOR and PTEN expression.
Correlation coefficient was calculated using Pearson’s correlation test.
The 3-year overall survival (OS) and disease-free survival (DFS) were calculated in relation to the two markers.
94 (63.5%) of 148 were mTOR high expression, and PTEN high expression was detected in 46 (31.1%) of the 148 patients with ESCC.
The Pearson correlation coefficient revealed a significant negative correlation in two proteins (correlation coefficient = −0.189, P < 0.005 ).
The 3-year OS and DFS time in the mTOR-high group was 23.9 and 18.4 months, respectively, and the time in the mTOR-low group was 33.9 months and 31.4 months, respectively.
The difference of survival rate between the two groups remained statistically significant.
mTOR-low or PTEN-high patients had better 3-year rates of OS and DFS than mTOR-high or PTEN-low group ( P < 0.001 by the log-rank test).
This study also found that mTOR was an independence prognostic factor by multivariate analysis.
American Psychological Association (APA)
Lu, Jianjun& Pan, You& Xia, Xin& Gu, Yong& Lei, Yiyan. 2015. Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055407
Modern Language Association (MLA)
Lu, Jianjun…[et al.]. Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055407
American Medical Association (AMA)
Lu, Jianjun& Pan, You& Xia, Xin& Gu, Yong& Lei, Yiyan. Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055407