A Novel Microbisporicin Producer Identified by Early Dereplication during Lantibiotic Screening
المؤلفون المشاركون
Carrano, Lucia
Abbondi, Monica
Turconi, Paola
Candiani, Gianpaolo
Marinelli, Flavia
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
With the increasing need of effective antibiotics against multi-drug resistant pathogens, lantibiotics are an attractive option of a new class of molecules.
They are ribosomally synthetized and posttranslationally modified peptides possessing potent antimicrobial activity against aerobic and anaerobic Gram-positive pathogens, including those increasingly resistant to β-lactams and glycopeptides.
Some of them (actagardine, mersacidin, planosporicin, and microbisporicin) inhibit cell wall biosynthesis in pathogens and their effect is not antagonized by vancomycin.
Hereby, we apply an efficient strategy for lantibiotic screening to 240 members of a newly described genus of filamentous actinomycetes, named Actinoallomurus, that is considered a yet-poorly-exploited promising source for novel bioactive metabolites.
By combining antimicrobial differential assay against Staphylococcus aureus and its L-form (also in the presence of a β-lactamase cocktail or Ac-Lys-D-alanyl-D-alanine tripeptide), with LC-UV-MS dereplication coupled with bioautography, a novel producer of the potent microbisporicin complex was rapidly identified.
Under the commercial name of NAI-107, it is currently in late preclinical phase for the treatment of multi-drug resistant Gram-positive pathogens.
To our knowledge, this is the first report on a lantibiotic produced by an Actinoallomurus sp.
and on a microbisporicin producer not belonging to the Microbispora genus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Carrano, Lucia& Abbondi, Monica& Turconi, Paola& Candiani, Gianpaolo& Marinelli, Flavia. 2015. A Novel Microbisporicin Producer Identified by Early Dereplication during Lantibiotic Screening. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055421
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Carrano, Lucia…[et al.]. A Novel Microbisporicin Producer Identified by Early Dereplication during Lantibiotic Screening. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055421
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Carrano, Lucia& Abbondi, Monica& Turconi, Paola& Candiani, Gianpaolo& Marinelli, Flavia. A Novel Microbisporicin Producer Identified by Early Dereplication during Lantibiotic Screening. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055421
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055421
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر