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Curcumin Mitigates Accelerated Aging after Irradiation in Drosophila by Reducing Oxidative Stress
المؤلفون المشاركون
Seong, Ki Moon
Yu, Mira
Lee, Kyu-Sun
Park, Sunhoo
Jin, Young Woo
Min, Kyung-Jin
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Curcumin, belonging to a class of natural phenol compounds, has been extensively studied due to its antioxidative, anticancer, anti-inflammatory, and antineurodegenerative effects.
Recently, it has been shown to exert dual activities after irradiation, radioprotection, and radiosensitization.
Here, we investigated the protective effect of curcumin against radiation damage using D.
melanogaster.
Pretreatment with curcumin (100 μ M) recovered the shortened lifespan caused by irradiation and increased eclosion rate.
Flies subjected to high-dose irradiation showed a mutant phenotype of outstretched wings, whereas curcumin pretreatment reduced incidence of the mutant phenotype.
Protein carbonylation and formation of γ H2Ax foci both increased following high-dose irradiation most likely due to generation of reactive oxygen species.
Curcumin pretreatment reduced the amount of protein carbonylation as well as formation of γ H2Ax foci.
Therefore, we suggest that curcumin acts as an oxidative stress reducer as well as an effective protective agent against radiation damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Seong, Ki Moon& Yu, Mira& Lee, Kyu-Sun& Park, Sunhoo& Jin, Young Woo& Min, Kyung-Jin. 2015. Curcumin Mitigates Accelerated Aging after Irradiation in Drosophila by Reducing Oxidative Stress. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055440
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Seong, Ki Moon…[et al.]. Curcumin Mitigates Accelerated Aging after Irradiation in Drosophila by Reducing Oxidative Stress. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055440
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Seong, Ki Moon& Yu, Mira& Lee, Kyu-Sun& Park, Sunhoo& Jin, Young Woo& Min, Kyung-Jin. Curcumin Mitigates Accelerated Aging after Irradiation in Drosophila by Reducing Oxidative Stress. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055440
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055440
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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