Curcumin Mitigates Accelerated Aging after Irradiation in Drosophila by Reducing Oxidative Stress
Joint Authors
Seong, Ki Moon
Yu, Mira
Lee, Kyu-Sun
Park, Sunhoo
Jin, Young Woo
Min, Kyung-Jin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Curcumin, belonging to a class of natural phenol compounds, has been extensively studied due to its antioxidative, anticancer, anti-inflammatory, and antineurodegenerative effects.
Recently, it has been shown to exert dual activities after irradiation, radioprotection, and radiosensitization.
Here, we investigated the protective effect of curcumin against radiation damage using D.
melanogaster.
Pretreatment with curcumin (100 μ M) recovered the shortened lifespan caused by irradiation and increased eclosion rate.
Flies subjected to high-dose irradiation showed a mutant phenotype of outstretched wings, whereas curcumin pretreatment reduced incidence of the mutant phenotype.
Protein carbonylation and formation of γ H2Ax foci both increased following high-dose irradiation most likely due to generation of reactive oxygen species.
Curcumin pretreatment reduced the amount of protein carbonylation as well as formation of γ H2Ax foci.
Therefore, we suggest that curcumin acts as an oxidative stress reducer as well as an effective protective agent against radiation damage.
American Psychological Association (APA)
Seong, Ki Moon& Yu, Mira& Lee, Kyu-Sun& Park, Sunhoo& Jin, Young Woo& Min, Kyung-Jin. 2015. Curcumin Mitigates Accelerated Aging after Irradiation in Drosophila by Reducing Oxidative Stress. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055440
Modern Language Association (MLA)
Seong, Ki Moon…[et al.]. Curcumin Mitigates Accelerated Aging after Irradiation in Drosophila by Reducing Oxidative Stress. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055440
American Medical Association (AMA)
Seong, Ki Moon& Yu, Mira& Lee, Kyu-Sun& Park, Sunhoo& Jin, Young Woo& Min, Kyung-Jin. Curcumin Mitigates Accelerated Aging after Irradiation in Drosophila by Reducing Oxidative Stress. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055440