A Novel Animal Model of Impaired Glucose Tolerance Induced by the Interaction of Vitamin E Deficiency and 60Co Radiation
المؤلفون المشاركون
Guan, Yue
Cheng, Yan
Yin, Ying
Duan, Jialin
Wei, Guo
Weng, Yan
Guo, Chao
Zhu, Yanrong
Wang, Yanhua
Wen, Ai-dong
Xi, Miao-Miao
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-14
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Impaired glucose tolerance (IGT), known as the prediabetes stage, is usually induced by habits of life or environmental factors.
Established IGT animal models are mostly conducted with chemical compounds such as streptozocin or genetic modification.
However, the occasion of exposure to these factors in daily life is seldom.
The objective of this study was to establish a new animal model of IGT induced by VE deficiency in diet and exposure to radiation.
SD rats were treated individually or in combination of these two factors.
In the combination group, the calculated insulin sensitivity index decreased; then HOMA-β value increased.
Oxidative damage and IGT were observed.
Insulin secretion level in perfusate from pancreas response to glucose was characterized by a rapid but reduced first phase and an obviously defective second phase upon pancreas perfusion.
Histopathological images demonstrated the pathological changes.
Western blotting analysis showed that the insulin signaling pathway was downregulated.
The interaction of VE deficiency in diet and exposure to radiation could break the equilibrium of oxidation and antioxidation and result in IGT.
More importantly, a new IGT model was successfully established which may be conducive to further research into development of drugs against human IGT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guan, Yue& Cheng, Yan& Yin, Ying& Duan, Jialin& Wei, Guo& Weng, Yan…[et al.]. 2015. A Novel Animal Model of Impaired Glucose Tolerance Induced by the Interaction of Vitamin E Deficiency and 60Co Radiation. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055541
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guan, Yue…[et al.]. A Novel Animal Model of Impaired Glucose Tolerance Induced by the Interaction of Vitamin E Deficiency and 60Co Radiation. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055541
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guan, Yue& Cheng, Yan& Yin, Ying& Duan, Jialin& Wei, Guo& Weng, Yan…[et al.]. A Novel Animal Model of Impaired Glucose Tolerance Induced by the Interaction of Vitamin E Deficiency and 60Co Radiation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055541
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055541
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر