A Novel Animal Model of Impaired Glucose Tolerance Induced by the Interaction of Vitamin E Deficiency and 60Co Radiation
Joint Authors
Guan, Yue
Cheng, Yan
Yin, Ying
Duan, Jialin
Wei, Guo
Weng, Yan
Guo, Chao
Zhu, Yanrong
Wang, Yanhua
Wen, Ai-dong
Xi, Miao-Miao
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Impaired glucose tolerance (IGT), known as the prediabetes stage, is usually induced by habits of life or environmental factors.
Established IGT animal models are mostly conducted with chemical compounds such as streptozocin or genetic modification.
However, the occasion of exposure to these factors in daily life is seldom.
The objective of this study was to establish a new animal model of IGT induced by VE deficiency in diet and exposure to radiation.
SD rats were treated individually or in combination of these two factors.
In the combination group, the calculated insulin sensitivity index decreased; then HOMA-β value increased.
Oxidative damage and IGT were observed.
Insulin secretion level in perfusate from pancreas response to glucose was characterized by a rapid but reduced first phase and an obviously defective second phase upon pancreas perfusion.
Histopathological images demonstrated the pathological changes.
Western blotting analysis showed that the insulin signaling pathway was downregulated.
The interaction of VE deficiency in diet and exposure to radiation could break the equilibrium of oxidation and antioxidation and result in IGT.
More importantly, a new IGT model was successfully established which may be conducive to further research into development of drugs against human IGT.
American Psychological Association (APA)
Guan, Yue& Cheng, Yan& Yin, Ying& Duan, Jialin& Wei, Guo& Weng, Yan…[et al.]. 2015. A Novel Animal Model of Impaired Glucose Tolerance Induced by the Interaction of Vitamin E Deficiency and 60Co Radiation. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055541
Modern Language Association (MLA)
Guan, Yue…[et al.]. A Novel Animal Model of Impaired Glucose Tolerance Induced by the Interaction of Vitamin E Deficiency and 60Co Radiation. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055541
American Medical Association (AMA)
Guan, Yue& Cheng, Yan& Yin, Ying& Duan, Jialin& Wei, Guo& Weng, Yan…[et al.]. A Novel Animal Model of Impaired Glucose Tolerance Induced by the Interaction of Vitamin E Deficiency and 60Co Radiation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055541
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055541