Improvement of BMI after Lifestyle Intervention Is Associated with Normalisation of Elevated ELF Score and Liver Stiffness in Obese Children
المؤلفون المشاركون
Goldschmidt, Imeke
Di Nanni, André
Streckenbach, Carolin
Schnell, Kerstin
Danne, Thomas
Baumann, Ulrich
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Noninvasive tools to diagnose nonalcoholic fatty liver disease (NAFLD), including transient elastography (TE) and enhanced liver fibrosis panel (ELF), have only been evaluated in children with biopsy-proven NAFLD.
We evaluated the prevalence of ELF and TE abnormalities in obese children without clinical liver disease and examined the effects of BMI stabilization on ELF and TE in a longitudinal approach.
Methods.
39 obese children (17 m, age 12.3 (7.6–17.4) years) who participated in a 12-month lifestyle-intervention program underwent TE and ELF testing at baseline and at completion of the program.
Results were compared with data from a nonobese paediatric cohort.
Results.
TE and ELF at baseline were significantly elevated compared to controls (TE: 5.9 (3.4–8.3) kPa versus 4.45 (2.45–8.85) kPa, P < 0.01 ; ELF: 9.0 (7.87–9.60) versus 8.6 (7.33–11.52), P = 0.033 ).
All children with elevated TE and ELF results had normal transaminases.
After the program, ELF and TE normalized.
Reduction of ELF and TE was associated with a decrease in BMI centile.
Conclusion.
Abnormal TE and ELF results in obese children suggest presence of NAFLD even when transaminases are normal.
TE and ELF might be used as monitoring tools for NAFLD.
BMI stabilisation normalizes TE and ELF, underlining the impact of lifestyle intervention.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Goldschmidt, Imeke& Di Nanni, André& Streckenbach, Carolin& Schnell, Kerstin& Danne, Thomas& Baumann, Ulrich. 2015. Improvement of BMI after Lifestyle Intervention Is Associated with Normalisation of Elevated ELF Score and Liver Stiffness in Obese Children. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055544
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Goldschmidt, Imeke…[et al.]. Improvement of BMI after Lifestyle Intervention Is Associated with Normalisation of Elevated ELF Score and Liver Stiffness in Obese Children. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055544
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Goldschmidt, Imeke& Di Nanni, André& Streckenbach, Carolin& Schnell, Kerstin& Danne, Thomas& Baumann, Ulrich. Improvement of BMI after Lifestyle Intervention Is Associated with Normalisation of Elevated ELF Score and Liver Stiffness in Obese Children. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055544
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055544
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر