PTEN Plays an Important Role in Thrombin-Mediated Lung Cancer Cell Functions

المؤلفون المشاركون

Xu, Zhishan
Zhu, Lingyun
Yao, Min
Zhong, Genshen
Dong, Qiaoyan
Yu, Aiping

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-03-11

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Thrombin and its membrane receptor, protease-activated receptor 1 (PAR1), have been reported to promote the development of lung cancer in vitro and in vivo.

However, the intracellular molecular mechanism or signaling pathway that mediates the cytological effects after the thrombin-receptor interaction is poorly understood.

Our previous study observed that the expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was downregulated in thrombin-stimulated lung cancer.

In this study, the role of PTEN in thrombin-mediated cell function and the corresponding cell signaling pathway were studied in lung cancer cell Glc-82.

The results indicated that thrombin downregulates the PTEN expression level and that PTEN plays an important role in thrombin-mediated Glc-82 functions, including cell cycle progression, cell apoptosis, and cell migration.

The PI3K/AKT signaling pathway and its related proteins, including p27 and S phase kinase associated protein 2 (Skp2), are involved in the effects induced by PTEN downregulation.

PAR1 plays a role in thrombin-mediated reduction of PTEN expression.

This study suggested that the PTEN/PI3K/AKT signaling pathway plays an important role in thrombin/PAR1-mediated lung cancer cell growth and migration.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xu, Zhishan& Zhu, Lingyun& Yao, Min& Zhong, Genshen& Dong, Qiaoyan& Yu, Aiping. 2015. PTEN Plays an Important Role in Thrombin-Mediated Lung Cancer Cell Functions. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055552

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xu, Zhishan…[et al.]. PTEN Plays an Important Role in Thrombin-Mediated Lung Cancer Cell Functions. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055552

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xu, Zhishan& Zhu, Lingyun& Yao, Min& Zhong, Genshen& Dong, Qiaoyan& Yu, Aiping. PTEN Plays an Important Role in Thrombin-Mediated Lung Cancer Cell Functions. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055552

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1055552