PTEN Plays an Important Role in Thrombin-Mediated Lung Cancer Cell Functions
Joint Authors
Xu, Zhishan
Zhu, Lingyun
Yao, Min
Zhong, Genshen
Dong, Qiaoyan
Yu, Aiping
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Thrombin and its membrane receptor, protease-activated receptor 1 (PAR1), have been reported to promote the development of lung cancer in vitro and in vivo.
However, the intracellular molecular mechanism or signaling pathway that mediates the cytological effects after the thrombin-receptor interaction is poorly understood.
Our previous study observed that the expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was downregulated in thrombin-stimulated lung cancer.
In this study, the role of PTEN in thrombin-mediated cell function and the corresponding cell signaling pathway were studied in lung cancer cell Glc-82.
The results indicated that thrombin downregulates the PTEN expression level and that PTEN plays an important role in thrombin-mediated Glc-82 functions, including cell cycle progression, cell apoptosis, and cell migration.
The PI3K/AKT signaling pathway and its related proteins, including p27 and S phase kinase associated protein 2 (Skp2), are involved in the effects induced by PTEN downregulation.
PAR1 plays a role in thrombin-mediated reduction of PTEN expression.
This study suggested that the PTEN/PI3K/AKT signaling pathway plays an important role in thrombin/PAR1-mediated lung cancer cell growth and migration.
American Psychological Association (APA)
Xu, Zhishan& Zhu, Lingyun& Yao, Min& Zhong, Genshen& Dong, Qiaoyan& Yu, Aiping. 2015. PTEN Plays an Important Role in Thrombin-Mediated Lung Cancer Cell Functions. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055552
Modern Language Association (MLA)
Xu, Zhishan…[et al.]. PTEN Plays an Important Role in Thrombin-Mediated Lung Cancer Cell Functions. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055552
American Medical Association (AMA)
Xu, Zhishan& Zhu, Lingyun& Yao, Min& Zhong, Genshen& Dong, Qiaoyan& Yu, Aiping. PTEN Plays an Important Role in Thrombin-Mediated Lung Cancer Cell Functions. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055552