Changes in B-Cell Counts and Percentages during Primary HIV Infection Associated with Disease Progression in HIV-Infected Men Who Have Sex with Men: A Preliminary Study
المؤلفون المشاركون
Xu, Jun-Jie
Chu, Zhen-Xing
Cui, Chen
Shang, Hong
Zhao, Bin
Ding, Haibo
Zhang, Zining
Han, Xiaoxu
Liu, Jing
Cao, Yaming
Jiang, Yong-Jun
Hu, Qing-Hai
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-07
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Numerous anomalies in B-cell phenotypes and functions have been described in HIV-infected individuals.
However, the actual relationship between B cells and disease progression remains unclear.
In this study, we investigated B-cell counts/percentages during a 12-month infection period in HIV-infected individuals that eventually developed into typical progressors (TPs) or rapid progressors (RPs).
We found, after 12 months of infection, the baseline B-cell counts/percentages correlated positively with CD4+ T-cell counts (P=0.0006 and P=0.026) and negatively with HIV viral set points (P=0.014 and P=0.002).
Kaplan-Meier survival analysis showed that high baseline B-cell counts/percentages were associated with a slow CD4-cell decline.
B-cell kinetics indicated the baseline B-cell counts/percentages could be factors distinguishing between TPs and RPs.
The combination of the baseline B-cell counts and percentages was associated with rapid disease progression (a 80.7% predictive value as measured by the area under the curve).
These results indicate that the baseline B-cell counts/percentages might be associated with HIV disease progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cui, Chen& Jiang, Yong-Jun& Zhang, Zining& Hu, Qing-Hai& Chu, Zhen-Xing& Xu, Jun-Jie…[et al.]. 2015. Changes in B-Cell Counts and Percentages during Primary HIV Infection Associated with Disease Progression in HIV-Infected Men Who Have Sex with Men: A Preliminary Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1055591
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cui, Chen…[et al.]. Changes in B-Cell Counts and Percentages during Primary HIV Infection Associated with Disease Progression in HIV-Infected Men Who Have Sex with Men: A Preliminary Study. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1055591
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cui, Chen& Jiang, Yong-Jun& Zhang, Zining& Hu, Qing-Hai& Chu, Zhen-Xing& Xu, Jun-Jie…[et al.]. Changes in B-Cell Counts and Percentages during Primary HIV Infection Associated with Disease Progression in HIV-Infected Men Who Have Sex with Men: A Preliminary Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1055591
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055591
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر