Changes in B-Cell Counts and Percentages during Primary HIV Infection Associated with Disease Progression in HIV-Infected Men Who Have Sex with Men: A Preliminary Study
Joint Authors
Xu, Jun-Jie
Chu, Zhen-Xing
Cui, Chen
Shang, Hong
Zhao, Bin
Ding, Haibo
Zhang, Zining
Han, Xiaoxu
Liu, Jing
Cao, Yaming
Jiang, Yong-Jun
Hu, Qing-Hai
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-07
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Numerous anomalies in B-cell phenotypes and functions have been described in HIV-infected individuals.
However, the actual relationship between B cells and disease progression remains unclear.
In this study, we investigated B-cell counts/percentages during a 12-month infection period in HIV-infected individuals that eventually developed into typical progressors (TPs) or rapid progressors (RPs).
We found, after 12 months of infection, the baseline B-cell counts/percentages correlated positively with CD4+ T-cell counts (P=0.0006 and P=0.026) and negatively with HIV viral set points (P=0.014 and P=0.002).
Kaplan-Meier survival analysis showed that high baseline B-cell counts/percentages were associated with a slow CD4-cell decline.
B-cell kinetics indicated the baseline B-cell counts/percentages could be factors distinguishing between TPs and RPs.
The combination of the baseline B-cell counts and percentages was associated with rapid disease progression (a 80.7% predictive value as measured by the area under the curve).
These results indicate that the baseline B-cell counts/percentages might be associated with HIV disease progression.
American Psychological Association (APA)
Cui, Chen& Jiang, Yong-Jun& Zhang, Zining& Hu, Qing-Hai& Chu, Zhen-Xing& Xu, Jun-Jie…[et al.]. 2015. Changes in B-Cell Counts and Percentages during Primary HIV Infection Associated with Disease Progression in HIV-Infected Men Who Have Sex with Men: A Preliminary Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1055591
Modern Language Association (MLA)
Cui, Chen…[et al.]. Changes in B-Cell Counts and Percentages during Primary HIV Infection Associated with Disease Progression in HIV-Infected Men Who Have Sex with Men: A Preliminary Study. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1055591
American Medical Association (AMA)
Cui, Chen& Jiang, Yong-Jun& Zhang, Zining& Hu, Qing-Hai& Chu, Zhen-Xing& Xu, Jun-Jie…[et al.]. Changes in B-Cell Counts and Percentages during Primary HIV Infection Associated with Disease Progression in HIV-Infected Men Who Have Sex with Men: A Preliminary Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1055591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055591