Dissociation of Calcium Transients and Force Development following a Change in Stimulation Frequency in Isolated Rabbit Myocardium
المؤلفون المشاركون
Janssen, Paul M. L.
Davis, Jonathan P.
Varian, Kenneth D.
Haizlip, Kaylan M.
Milani-Nejad, Nima
Brunello, Lucia
Slabaugh, Jessica L.
Walton, Shane D.
Gyorke, Sandor
Biesiadecki, Brandon J.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
As the heart transitions from one exercise intensity to another, changes in cardiac output occur, which are modulated by alterations in force development and calcium handling.
Although the steady-state force-calcium relationship at various heart rates is well investigated, regulation of these processes during transitions in heart rate is poorly understood.
In isolated right ventricular muscle preparations from the rabbit, we investigated the beat-to-beat alterations in force and calcium during the transition from one stimulation frequency to another, using contractile assessments and confocal microscopy.
We show that a change in steady-state conditions occurs in multiple phases: a rapid phase, which is characterized by a fast change in force production mirrored by a change in calcium transient amplitude, and a slow phase, which follows the rapid phase and occurs as the muscle proceeds to stabilize at the new frequency.
This second/late phase is characterized by a quantitative dissociation between the calcium transient amplitude and developed force.
Twitch timing kinetics, such as time to peak tension and 50% relaxation rate, reached steady-state well before force development and calcium transient amplitude.
The dynamic relationship between force and calcium upon a switch in stimulation frequency unveils the dynamic involvement of myofilament-based properties in frequency-dependent activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Haizlip, Kaylan M.& Milani-Nejad, Nima& Brunello, Lucia& Varian, Kenneth D.& Slabaugh, Jessica L.& Walton, Shane D.…[et al.]. 2015. Dissociation of Calcium Transients and Force Development following a Change in Stimulation Frequency in Isolated Rabbit Myocardium. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055594
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Haizlip, Kaylan M.…[et al.]. Dissociation of Calcium Transients and Force Development following a Change in Stimulation Frequency in Isolated Rabbit Myocardium. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055594
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Haizlip, Kaylan M.& Milani-Nejad, Nima& Brunello, Lucia& Varian, Kenneth D.& Slabaugh, Jessica L.& Walton, Shane D.…[et al.]. Dissociation of Calcium Transients and Force Development following a Change in Stimulation Frequency in Isolated Rabbit Myocardium. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055594
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055594
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر