Localized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury
المؤلفون المشاركون
Zhang, Wei
Gao, Yuan
Zhou, Yan
Liu, Jianheng
Zhang, Licheng
Long, Anhua
Zhang, Lihai
Tang, Peifu
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Erythropoietin (EPO) has been demonstrated to exert neuroprotective effects on peripheral nerve injury recovery.
Though daily intraperitoneal injection of EPO during a long period of time was effective, it was a tedious procedure.
In addition, only limited amount of EPO could reach the injury sites by general administration, and free EPO is easily degraded in vivo.
In this study, we encapsulated EPO in poly(lactide-co-glycolide) (PLGA) microspheres.
Both in vitro and in vivo release assays showed that the EPO-PLGA microspheres allowed sustained release of EPO within a period of two weeks.
After administration of such EPO-PLGA microspheres, the peripheral nerve injured rats had significantly better recovery compared with those which received daily intraperitoneal injection of EPO, empty PLGA microspheres, or saline treatments.
This was supported by the functional, electrophysiological, and histological evaluations of the recovery done at week 8 postoperatively.
We conclude that sustained delivery of EPO could be achieved by using EPO-PLGA microspheres, and such delivery method could further enhance the recovery function of EPO in nerve injury recovery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Wei& Gao, Yuan& Zhou, Yan& Liu, Jianheng& Zhang, Licheng& Long, Anhua…[et al.]. 2015. Localized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055627
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Wei…[et al.]. Localized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055627
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Wei& Gao, Yuan& Zhou, Yan& Liu, Jianheng& Zhang, Licheng& Long, Anhua…[et al.]. Localized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055627
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055627
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر