Localized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury
Joint Authors
Zhang, Wei
Gao, Yuan
Zhou, Yan
Liu, Jianheng
Zhang, Licheng
Long, Anhua
Zhang, Lihai
Tang, Peifu
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Erythropoietin (EPO) has been demonstrated to exert neuroprotective effects on peripheral nerve injury recovery.
Though daily intraperitoneal injection of EPO during a long period of time was effective, it was a tedious procedure.
In addition, only limited amount of EPO could reach the injury sites by general administration, and free EPO is easily degraded in vivo.
In this study, we encapsulated EPO in poly(lactide-co-glycolide) (PLGA) microspheres.
Both in vitro and in vivo release assays showed that the EPO-PLGA microspheres allowed sustained release of EPO within a period of two weeks.
After administration of such EPO-PLGA microspheres, the peripheral nerve injured rats had significantly better recovery compared with those which received daily intraperitoneal injection of EPO, empty PLGA microspheres, or saline treatments.
This was supported by the functional, electrophysiological, and histological evaluations of the recovery done at week 8 postoperatively.
We conclude that sustained delivery of EPO could be achieved by using EPO-PLGA microspheres, and such delivery method could further enhance the recovery function of EPO in nerve injury recovery.
American Psychological Association (APA)
Zhang, Wei& Gao, Yuan& Zhou, Yan& Liu, Jianheng& Zhang, Licheng& Long, Anhua…[et al.]. 2015. Localized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055627
Modern Language Association (MLA)
Zhang, Wei…[et al.]. Localized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055627
American Medical Association (AMA)
Zhang, Wei& Gao, Yuan& Zhou, Yan& Liu, Jianheng& Zhang, Licheng& Long, Anhua…[et al.]. Localized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055627
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055627