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Cholinergic Synaptic Transmissions Were Altered after Single Sevoflurane Exposure in Drosophila Pupa
المؤلفون المشاركون
Chen, Rongfa
Zhang, Tao
Kuang, Liting
Chen, Zhen
Ran, Dongzhi
Niu, Yang
Xu, Kangqing
Gu, Huaiyu
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
Sevoflurane, one of the most used general anesthetics, is widely used in clinical practice all over the world.
Previous studies indicated that sevoflurane could induce neuron apoptosis and neural deficit causing query in the safety of anesthesia using sevoflurane.
The present study was designed to investigate the effects of sevoflurane on electrophysiology in Drosophila pupa whose excitatory neurotransmitter is acetylcholine early after sevoflurane exposure using whole brain recording technique.
Methods.
Wide types of Drosophila (canton-s flies) were allocated to control and sevoflurane groups randomly.
Sevoflurane groups (1% sevoflurane; 2% sevoflurane; 3% sevoflurane) were exposed to sevoflurane and the exposure lasted 5 hours, respectively.
All flies were subjected to electrophysiology experiment using patch clamp 24 hours after exposure.
Results.
The results showed that, 24 hours after sevoflurane exposure, frequency but not the amplitude of miniature excitatory postsynaptic currents (mEPSCs) was significantly reduced P<0.05.
Furthermore, we explored the underlying mechanism and found that calcium currents density, which partially regulated the frequency of mEPSCs, was significantly reduced after sevoflurane exposure P<0.05.
Conclusions.
All these suggested that sevoflurane could alter the mEPSCs that are related to synaptic plasticity partially through modulating calcium channel early after sevoflurane exposure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Rongfa& Zhang, Tao& Kuang, Liting& Chen, Zhen& Ran, Dongzhi& Niu, Yang…[et al.]. 2015. Cholinergic Synaptic Transmissions Were Altered after Single Sevoflurane Exposure in Drosophila Pupa. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055659
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Rongfa…[et al.]. Cholinergic Synaptic Transmissions Were Altered after Single Sevoflurane Exposure in Drosophila Pupa. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055659
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Rongfa& Zhang, Tao& Kuang, Liting& Chen, Zhen& Ran, Dongzhi& Niu, Yang…[et al.]. Cholinergic Synaptic Transmissions Were Altered after Single Sevoflurane Exposure in Drosophila Pupa. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055659
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055659
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