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Effects of Sucroferric Oxyhydroxide Compared to Lanthanum Carbonate and Sevelamer Carbonate on Phosphate Homeostasis and Vascular Calcifications in a Rat Model of Chronic Kidney Failure
المؤلفون المشاركون
Phan, Olivier
Maillard, Marc
Malluche, Hartmut H.
Stehle, Jean-Christophe
Funk, Felix
Burnier, Michel
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Elevated serum phosphorus, calcium, and fibroblast growth factor 23 (FGF23) levels are associated with cardiovascular disease in chronic renal disease.
This study evaluated the effects of sucroferric oxyhydroxide (PA21), a new iron-based phosphate binder, versus lanthanum carbonate (La) and sevelamer carbonate (Se), on serum FGF23, phosphorus, calcium, and intact parathyroid hormone (iPTH) concentrations, and the development of vascular calcification in adenine-induced chronic renal failure (CRF) rats.
After induction of CRF, renal function was significantly impaired in all groups: uremic rats developed severe hyperphosphatemia, and serum iPTH increased significantly.
All uremic rats (except controls) then received phosphate binders for 4 weeks.
Hyperphosphatemia and increased serum iPTH were controlled to a similar extent in all phosphate binder-treatment groups.
Only sucroferric oxyhydroxide was associated with significantly decreased FGF23.
Vascular calcifications of the thoracic aorta were decreased by all three phosphate binders.
Calcifications were better prevented at the superior part of the thoracic and abdominal aorta in the PA21 treated rats.
In adenine-induced CRF rats, sucroferric oxyhydroxide was as effective as La and Se in controlling hyperphosphatemia, secondary hyperparathyroidism, and vascular calcifications.
The role of FGF23 in calcification remains to be confirmed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Phan, Olivier& Maillard, Marc& Malluche, Hartmut H.& Stehle, Jean-Christophe& Funk, Felix& Burnier, Michel. 2015. Effects of Sucroferric Oxyhydroxide Compared to Lanthanum Carbonate and Sevelamer Carbonate on Phosphate Homeostasis and Vascular Calcifications in a Rat Model of Chronic Kidney Failure. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055782
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Phan, Olivier…[et al.]. Effects of Sucroferric Oxyhydroxide Compared to Lanthanum Carbonate and Sevelamer Carbonate on Phosphate Homeostasis and Vascular Calcifications in a Rat Model of Chronic Kidney Failure. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055782
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Phan, Olivier& Maillard, Marc& Malluche, Hartmut H.& Stehle, Jean-Christophe& Funk, Felix& Burnier, Michel. Effects of Sucroferric Oxyhydroxide Compared to Lanthanum Carbonate and Sevelamer Carbonate on Phosphate Homeostasis and Vascular Calcifications in a Rat Model of Chronic Kidney Failure. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055782
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055782
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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