Effects of Sucroferric Oxyhydroxide Compared to Lanthanum Carbonate and Sevelamer Carbonate on Phosphate Homeostasis and Vascular Calcifications in a Rat Model of Chronic Kidney Failure
Joint Authors
Phan, Olivier
Maillard, Marc
Malluche, Hartmut H.
Stehle, Jean-Christophe
Funk, Felix
Burnier, Michel
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Elevated serum phosphorus, calcium, and fibroblast growth factor 23 (FGF23) levels are associated with cardiovascular disease in chronic renal disease.
This study evaluated the effects of sucroferric oxyhydroxide (PA21), a new iron-based phosphate binder, versus lanthanum carbonate (La) and sevelamer carbonate (Se), on serum FGF23, phosphorus, calcium, and intact parathyroid hormone (iPTH) concentrations, and the development of vascular calcification in adenine-induced chronic renal failure (CRF) rats.
After induction of CRF, renal function was significantly impaired in all groups: uremic rats developed severe hyperphosphatemia, and serum iPTH increased significantly.
All uremic rats (except controls) then received phosphate binders for 4 weeks.
Hyperphosphatemia and increased serum iPTH were controlled to a similar extent in all phosphate binder-treatment groups.
Only sucroferric oxyhydroxide was associated with significantly decreased FGF23.
Vascular calcifications of the thoracic aorta were decreased by all three phosphate binders.
Calcifications were better prevented at the superior part of the thoracic and abdominal aorta in the PA21 treated rats.
In adenine-induced CRF rats, sucroferric oxyhydroxide was as effective as La and Se in controlling hyperphosphatemia, secondary hyperparathyroidism, and vascular calcifications.
The role of FGF23 in calcification remains to be confirmed.
American Psychological Association (APA)
Phan, Olivier& Maillard, Marc& Malluche, Hartmut H.& Stehle, Jean-Christophe& Funk, Felix& Burnier, Michel. 2015. Effects of Sucroferric Oxyhydroxide Compared to Lanthanum Carbonate and Sevelamer Carbonate on Phosphate Homeostasis and Vascular Calcifications in a Rat Model of Chronic Kidney Failure. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055782
Modern Language Association (MLA)
Phan, Olivier…[et al.]. Effects of Sucroferric Oxyhydroxide Compared to Lanthanum Carbonate and Sevelamer Carbonate on Phosphate Homeostasis and Vascular Calcifications in a Rat Model of Chronic Kidney Failure. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055782
American Medical Association (AMA)
Phan, Olivier& Maillard, Marc& Malluche, Hartmut H.& Stehle, Jean-Christophe& Funk, Felix& Burnier, Michel. Effects of Sucroferric Oxyhydroxide Compared to Lanthanum Carbonate and Sevelamer Carbonate on Phosphate Homeostasis and Vascular Calcifications in a Rat Model of Chronic Kidney Failure. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055782