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Impact of Depression, Fatigue, and Global Measure of Cortical Volume on Cognitive Impairment in Multiple Sclerosis
المؤلفون المشاركون
Marino, Silvia
Nunnari, Domenica
De Cola, Maria Cristina
D’Aleo, Giangaetano
Rifici, Carmela
Russo, Margherita
Sessa, Edoardo
Bramanti, Placido
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the influence of demographic and clinical variables, such as depression, fatigue, and quantitative MRI marker on cognitive performances in a sample of patients affected by multiple sclerosis (MS).
Methods.
60 MS patients (52 relapsing remitting and 8 primary progressive) underwent neuropsychological assessments using Rao’s Brief Repeatable Battery of Neuropsychological Tests (BRB-N), the Beck Depression Inventory-second edition (BDI-II), and the Fatigue Severity Scale (FSS).
We performed magnetic resonance imaging to all subjects using a 3 T scanner and obtained tissue-specific volumes (normalized brain volume and cortical brain volume).
We used Student’s t-test to compare depressed and nondepressed MS patients.
Finally, we performed a multivariate regression analysis in order to assess possible predictors of patients’ cognitive outcome among demographic and clinical variables.
Results.
27.12% of the sample (16/59) was cognitively impaired, especially in tasks requiring attention and information processing speed.
From between group comparison, we find that depressed patients had worse performances on BRB-N score, greater disability and disease duration, and brain volume decrease.
According to multiple regression analysis, the BDI-II score was a significant predictor for most of the neuropsychological tests.
Conclusions.
Our findings suggest that the presence of depressive symptoms is an important determinant of cognitive performance in MS patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nunnari, Domenica& De Cola, Maria Cristina& D’Aleo, Giangaetano& Rifici, Carmela& Russo, Margherita& Sessa, Edoardo…[et al.]. 2015. Impact of Depression, Fatigue, and Global Measure of Cortical Volume on Cognitive Impairment in Multiple Sclerosis. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055799
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nunnari, Domenica…[et al.]. Impact of Depression, Fatigue, and Global Measure of Cortical Volume on Cognitive Impairment in Multiple Sclerosis. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055799
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nunnari, Domenica& De Cola, Maria Cristina& D’Aleo, Giangaetano& Rifici, Carmela& Russo, Margherita& Sessa, Edoardo…[et al.]. Impact of Depression, Fatigue, and Global Measure of Cortical Volume on Cognitive Impairment in Multiple Sclerosis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055799
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055799
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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