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Impact of Depression, Fatigue, and Global Measure of Cortical Volume on Cognitive Impairment in Multiple Sclerosis
Joint Authors
Marino, Silvia
Nunnari, Domenica
De Cola, Maria Cristina
D’Aleo, Giangaetano
Rifici, Carmela
Russo, Margherita
Sessa, Edoardo
Bramanti, Placido
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To investigate the influence of demographic and clinical variables, such as depression, fatigue, and quantitative MRI marker on cognitive performances in a sample of patients affected by multiple sclerosis (MS).
Methods.
60 MS patients (52 relapsing remitting and 8 primary progressive) underwent neuropsychological assessments using Rao’s Brief Repeatable Battery of Neuropsychological Tests (BRB-N), the Beck Depression Inventory-second edition (BDI-II), and the Fatigue Severity Scale (FSS).
We performed magnetic resonance imaging to all subjects using a 3 T scanner and obtained tissue-specific volumes (normalized brain volume and cortical brain volume).
We used Student’s t-test to compare depressed and nondepressed MS patients.
Finally, we performed a multivariate regression analysis in order to assess possible predictors of patients’ cognitive outcome among demographic and clinical variables.
Results.
27.12% of the sample (16/59) was cognitively impaired, especially in tasks requiring attention and information processing speed.
From between group comparison, we find that depressed patients had worse performances on BRB-N score, greater disability and disease duration, and brain volume decrease.
According to multiple regression analysis, the BDI-II score was a significant predictor for most of the neuropsychological tests.
Conclusions.
Our findings suggest that the presence of depressive symptoms is an important determinant of cognitive performance in MS patients.
American Psychological Association (APA)
Nunnari, Domenica& De Cola, Maria Cristina& D’Aleo, Giangaetano& Rifici, Carmela& Russo, Margherita& Sessa, Edoardo…[et al.]. 2015. Impact of Depression, Fatigue, and Global Measure of Cortical Volume on Cognitive Impairment in Multiple Sclerosis. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055799
Modern Language Association (MLA)
Nunnari, Domenica…[et al.]. Impact of Depression, Fatigue, and Global Measure of Cortical Volume on Cognitive Impairment in Multiple Sclerosis. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055799
American Medical Association (AMA)
Nunnari, Domenica& De Cola, Maria Cristina& D’Aleo, Giangaetano& Rifici, Carmela& Russo, Margherita& Sessa, Edoardo…[et al.]. Impact of Depression, Fatigue, and Global Measure of Cortical Volume on Cognitive Impairment in Multiple Sclerosis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055799