Biological Niches within Human Calcified Aortic Valves: Towards Understanding of the Pathological Biomineralization Process
المؤلفون المشاركون
Cottignoli, Valentina
Relucenti, Michela
Agrosì, Giovanna
Cavarretta, Elena
Familiari, Giuseppe
Salvador, Loris
Maras, Adriana
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Despite recent advances, mineralization site, its microarchitecture, and composition in calcific heart valve remain poorly understood.
A multiscale investigation, using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive X-ray spectrometry (EDS), from micrometre up to nanometre, was conducted on human severely calcified aortic and mitral valves, to provide new insights into calcification process.
Our aim was to evaluate the spatial relationship existing between bioapatite crystals, their local growing microenvironment, and the presence of a hierarchical architecture.
Here we detected the presence of bioapatite crystals in two different mineralization sites that suggest the action of two different growth processes: a pathological crystallization process that occurs in biological niches and is ascribed to a purely physicochemical process and a matrix-mediated mineralized process in which the extracellular matrix acts as the template for a site-directed nanocrystals nucleation.
Different shapes of bioapatite crystallization were observed at micrometer scale in each microenvironment but at the nanoscale level crystals appear to be made up by the same subunits.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cottignoli, Valentina& Relucenti, Michela& Agrosì, Giovanna& Cavarretta, Elena& Familiari, Giuseppe& Salvador, Loris…[et al.]. 2015. Biological Niches within Human Calcified Aortic Valves: Towards Understanding of the Pathological Biomineralization Process. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055887
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cottignoli, Valentina…[et al.]. Biological Niches within Human Calcified Aortic Valves: Towards Understanding of the Pathological Biomineralization Process. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055887
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cottignoli, Valentina& Relucenti, Michela& Agrosì, Giovanna& Cavarretta, Elena& Familiari, Giuseppe& Salvador, Loris…[et al.]. Biological Niches within Human Calcified Aortic Valves: Towards Understanding of the Pathological Biomineralization Process. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055887
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055887
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر