![](/images/graphics-bg.png)
Biological Niches within Human Calcified Aortic Valves: Towards Understanding of the Pathological Biomineralization Process
Joint Authors
Cottignoli, Valentina
Relucenti, Michela
Agrosì, Giovanna
Cavarretta, Elena
Familiari, Giuseppe
Salvador, Loris
Maras, Adriana
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Despite recent advances, mineralization site, its microarchitecture, and composition in calcific heart valve remain poorly understood.
A multiscale investigation, using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive X-ray spectrometry (EDS), from micrometre up to nanometre, was conducted on human severely calcified aortic and mitral valves, to provide new insights into calcification process.
Our aim was to evaluate the spatial relationship existing between bioapatite crystals, their local growing microenvironment, and the presence of a hierarchical architecture.
Here we detected the presence of bioapatite crystals in two different mineralization sites that suggest the action of two different growth processes: a pathological crystallization process that occurs in biological niches and is ascribed to a purely physicochemical process and a matrix-mediated mineralized process in which the extracellular matrix acts as the template for a site-directed nanocrystals nucleation.
Different shapes of bioapatite crystallization were observed at micrometer scale in each microenvironment but at the nanoscale level crystals appear to be made up by the same subunits.
American Psychological Association (APA)
Cottignoli, Valentina& Relucenti, Michela& Agrosì, Giovanna& Cavarretta, Elena& Familiari, Giuseppe& Salvador, Loris…[et al.]. 2015. Biological Niches within Human Calcified Aortic Valves: Towards Understanding of the Pathological Biomineralization Process. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055887
Modern Language Association (MLA)
Cottignoli, Valentina…[et al.]. Biological Niches within Human Calcified Aortic Valves: Towards Understanding of the Pathological Biomineralization Process. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055887
American Medical Association (AMA)
Cottignoli, Valentina& Relucenti, Michela& Agrosì, Giovanna& Cavarretta, Elena& Familiari, Giuseppe& Salvador, Loris…[et al.]. Biological Niches within Human Calcified Aortic Valves: Towards Understanding of the Pathological Biomineralization Process. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055887