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Imbalance of the Nerve Growth Factor and Its Precursor as a Potential Biomarker for Diabetic Retinopathy
المؤلفون المشاركون
Mysona, B. A.
Matragoon, S.
Stephens, M.
Mohamed, I. N.
Farooq, A.
Bartasis, M. L.
Fouda, A. Y.
Shanab, A. Y.
Espinosa-Heidmann, D. G.
El-Remessy, Azza B.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-17
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Our previous studies have demonstrated that diabetes-induced oxidative stress alters homeostasis of retinal nerve growth factor (NGF) resulting in accumulation of its precursor, proNGF, at the expense of NGF which plays a critical role in preserving neuronal and retinal function.
This imbalance coincided with retinal damage in experimental diabetes.
Here we test the hypothesis that alteration of proNGF and NGF levels observed in retina and vitreous will be mirrored in serum of diabetic patients.
Blood and vitreous samples were collected from patients (diabetic and nondiabetic) undergoing vitrectomy at Georgia Regents University under approved IRB.
Levels of proNGF, NGF, and p75NTR shedding were detected using Western blot analysis.
MMP-7 activity was also assayed.
Diabetes-induced proNGF expression and impaired NGF expression were observed in vitreous and serum.
Vitreous and sera from diabetic patients (n=11) showed significant 40.8-fold and 3.6-fold increases, respectively, compared to nondiabetics (n=9).
In contrast, vitreous and sera from diabetic patients showed significant 44% and 64% reductions in NGF levels, respectively, compared to nondiabetics.
ProNGF to NGF ratios showed significant correlation between vitreous and serum.
Further characterization of diabetes-induced imbalance in the proNGF to NGF ratio will facilitate its utility as an early biomarker for diabetic complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mysona, B. A.& Matragoon, S.& Stephens, M.& Mohamed, I. N.& Farooq, A.& Bartasis, M. L.…[et al.]. 2015. Imbalance of the Nerve Growth Factor and Its Precursor as a Potential Biomarker for Diabetic Retinopathy. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055956
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mysona, B. A.…[et al.]. Imbalance of the Nerve Growth Factor and Its Precursor as a Potential Biomarker for Diabetic Retinopathy. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055956
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mysona, B. A.& Matragoon, S.& Stephens, M.& Mohamed, I. N.& Farooq, A.& Bartasis, M. L.…[et al.]. Imbalance of the Nerve Growth Factor and Its Precursor as a Potential Biomarker for Diabetic Retinopathy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055956
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055956
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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