APOE Gene Polymorphism and Risk of Coronary Stenosis in Pakistani Population
المؤلفون المشاركون
Kamboh, M. Ilyas
Cheema, Asma Naseer
Bhatti, Attya
Ali, Jabar
Bamne, Mikhil N.
Wang, Xingbin
Demirci, F. Yesim
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-26
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Genetic variation in lipid regulatory genes, particularly APOE, significantly influences the risk of coronary artery disease (CAD).
This study aimed to assess the association between APOE polymorphism and angiographically assessed coronary stenosis in Pakistani population.
A total of 695 subjects (22.3% female, mean age = 54 ± 11 years) presenting with chest pain were enrolled after obtaining written informed consent.
CAD stenosis/extent was assessed by angiography.
Patients were classified as having severe stenosis (≥70%), moderate stenosis (30–69%), and mild stenosis (<30%).
CAD patients with ≥70% stenosis ( n = 491 ) were further categorized based on possessing one, two, or three vessel diseases to assess the disease extent.
Genomic DNA from leukocytes was isolated with DNA purification kit (Qiagen) and APOE polymorphisms (E2/E3/E4) were determined using TaqMan assays.
Six hundred and seventy-two of 695 subjects were successfully genotyped.
The frequency of APOE ∗ 4 carriers (3/4 and 4/4 genotypes) was significantly higher in severe stenosis group (≥70%) as compared to mild group (<30%) (22.8% versus 13.01%; P = 0.01 ).
In multiple regression, the odds ratio for APOE ∗ 4 carriers to develop ≥70% stenosis was 2.16 (95% CI: 1.29–3.79; P < 0.005 ).
In conclusion, the presence of APOE ∗ 4 allele is a significant risk factor to develop severe coronary stenosis (>70%) among Pakistanis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cheema, Asma Naseer& Bhatti, Attya& Wang, Xingbin& Ali, Jabar& Bamne, Mikhil N.& Demirci, F. Yesim…[et al.]. 2015. APOE Gene Polymorphism and Risk of Coronary Stenosis in Pakistani Population. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056024
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cheema, Asma Naseer…[et al.]. APOE Gene Polymorphism and Risk of Coronary Stenosis in Pakistani Population. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1056024
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cheema, Asma Naseer& Bhatti, Attya& Wang, Xingbin& Ali, Jabar& Bamne, Mikhil N.& Demirci, F. Yesim…[et al.]. APOE Gene Polymorphism and Risk of Coronary Stenosis in Pakistani Population. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056024
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056024
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر