APOE Gene Polymorphism and Risk of Coronary Stenosis in Pakistani Population
Joint Authors
Kamboh, M. Ilyas
Cheema, Asma Naseer
Bhatti, Attya
Ali, Jabar
Bamne, Mikhil N.
Wang, Xingbin
Demirci, F. Yesim
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Genetic variation in lipid regulatory genes, particularly APOE, significantly influences the risk of coronary artery disease (CAD).
This study aimed to assess the association between APOE polymorphism and angiographically assessed coronary stenosis in Pakistani population.
A total of 695 subjects (22.3% female, mean age = 54 ± 11 years) presenting with chest pain were enrolled after obtaining written informed consent.
CAD stenosis/extent was assessed by angiography.
Patients were classified as having severe stenosis (≥70%), moderate stenosis (30–69%), and mild stenosis (<30%).
CAD patients with ≥70% stenosis ( n = 491 ) were further categorized based on possessing one, two, or three vessel diseases to assess the disease extent.
Genomic DNA from leukocytes was isolated with DNA purification kit (Qiagen) and APOE polymorphisms (E2/E3/E4) were determined using TaqMan assays.
Six hundred and seventy-two of 695 subjects were successfully genotyped.
The frequency of APOE ∗ 4 carriers (3/4 and 4/4 genotypes) was significantly higher in severe stenosis group (≥70%) as compared to mild group (<30%) (22.8% versus 13.01%; P = 0.01 ).
In multiple regression, the odds ratio for APOE ∗ 4 carriers to develop ≥70% stenosis was 2.16 (95% CI: 1.29–3.79; P < 0.005 ).
In conclusion, the presence of APOE ∗ 4 allele is a significant risk factor to develop severe coronary stenosis (>70%) among Pakistanis.
American Psychological Association (APA)
Cheema, Asma Naseer& Bhatti, Attya& Wang, Xingbin& Ali, Jabar& Bamne, Mikhil N.& Demirci, F. Yesim…[et al.]. 2015. APOE Gene Polymorphism and Risk of Coronary Stenosis in Pakistani Population. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056024
Modern Language Association (MLA)
Cheema, Asma Naseer…[et al.]. APOE Gene Polymorphism and Risk of Coronary Stenosis in Pakistani Population. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1056024
American Medical Association (AMA)
Cheema, Asma Naseer& Bhatti, Attya& Wang, Xingbin& Ali, Jabar& Bamne, Mikhil N.& Demirci, F. Yesim…[et al.]. APOE Gene Polymorphism and Risk of Coronary Stenosis in Pakistani Population. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056024