Recombinant Human Thrombopoietin Treatment Promotes Hematopoiesis Recovery in Patients with Severe Aplastic Anemia Receiving Immunosuppressive Therapy
المؤلفون المشاركون
Shao, Zonghong
Wang, Huaquan
Dong, Qi’e
Qu, Wen
Ruan, Erbao
Wang, Guojin
Liu, Hong
Wu, Yuhong
Song, Jia
Xing, Limin
Guan, Jing
Li, Lijuan
Fu, Rong
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-11
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To assess the effectiveness of recombinant human thrombopoietin (rhTPO) in severe aplastic anemia (SAA) patients receiving immunosuppressive therapy (IST).
Methods.
Eighty-eight SAA patients receiving IST from January 2007 to December 2012 were included in this retrospective analysis.
Of these, 40 subjects received rhTPO treatment (15000 U, subcutaneously, three times a week).
rhTPO treatment was discontinued when the platelet count returned to normal range.
Hematologic response, bone marrow megakaryocyte recovery, and time to transfusion independence were compared.
Results.
Hematologic response was achieved in 42.5%, 62.5%, and 67.5% of patients receiving rhTPO and 22.9%, 41.6%, and 47.9% of patients not receiving rhTPO at 3, 6, and 9 months after treatment, respectively (P = 0.0665, P = 0.0579, and P = 0.0847, resp.).
Subjects receiving rhTPO presented an elevated number of megakaryocytes at 3, 6, and 9 months when compared with those without treatment (P = 0.025, P = 0.021, and P = 0.011, resp.).
The time to platelet and red blood cell transfusion independence was shorter in patients who received rhTPO than in those without rhTPO treatment.
Overall survival rate presented no differences between the two groups.
Conclusion.
rhTPO could improve hematologic response and promote bone marrow recovery in SAA patients receiving IST.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Huaquan& Dong, Qi’e& Fu, Rong& Qu, Wen& Ruan, Erbao& Wang, Guojin…[et al.]. 2015. Recombinant Human Thrombopoietin Treatment Promotes Hematopoiesis Recovery in Patients with Severe Aplastic Anemia Receiving Immunosuppressive Therapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056070
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Huaquan…[et al.]. Recombinant Human Thrombopoietin Treatment Promotes Hematopoiesis Recovery in Patients with Severe Aplastic Anemia Receiving Immunosuppressive Therapy. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056070
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Huaquan& Dong, Qi’e& Fu, Rong& Qu, Wen& Ruan, Erbao& Wang, Guojin…[et al.]. Recombinant Human Thrombopoietin Treatment Promotes Hematopoiesis Recovery in Patients with Severe Aplastic Anemia Receiving Immunosuppressive Therapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056070
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056070
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر