Recombinant Human Thrombopoietin Treatment Promotes Hematopoiesis Recovery in Patients with Severe Aplastic Anemia Receiving Immunosuppressive Therapy
Joint Authors
Shao, Zonghong
Wang, Huaquan
Dong, Qi’e
Qu, Wen
Ruan, Erbao
Wang, Guojin
Liu, Hong
Wu, Yuhong
Song, Jia
Xing, Limin
Guan, Jing
Li, Lijuan
Fu, Rong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To assess the effectiveness of recombinant human thrombopoietin (rhTPO) in severe aplastic anemia (SAA) patients receiving immunosuppressive therapy (IST).
Methods.
Eighty-eight SAA patients receiving IST from January 2007 to December 2012 were included in this retrospective analysis.
Of these, 40 subjects received rhTPO treatment (15000 U, subcutaneously, three times a week).
rhTPO treatment was discontinued when the platelet count returned to normal range.
Hematologic response, bone marrow megakaryocyte recovery, and time to transfusion independence were compared.
Results.
Hematologic response was achieved in 42.5%, 62.5%, and 67.5% of patients receiving rhTPO and 22.9%, 41.6%, and 47.9% of patients not receiving rhTPO at 3, 6, and 9 months after treatment, respectively (P = 0.0665, P = 0.0579, and P = 0.0847, resp.).
Subjects receiving rhTPO presented an elevated number of megakaryocytes at 3, 6, and 9 months when compared with those without treatment (P = 0.025, P = 0.021, and P = 0.011, resp.).
The time to platelet and red blood cell transfusion independence was shorter in patients who received rhTPO than in those without rhTPO treatment.
Overall survival rate presented no differences between the two groups.
Conclusion.
rhTPO could improve hematologic response and promote bone marrow recovery in SAA patients receiving IST.
American Psychological Association (APA)
Wang, Huaquan& Dong, Qi’e& Fu, Rong& Qu, Wen& Ruan, Erbao& Wang, Guojin…[et al.]. 2015. Recombinant Human Thrombopoietin Treatment Promotes Hematopoiesis Recovery in Patients with Severe Aplastic Anemia Receiving Immunosuppressive Therapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056070
Modern Language Association (MLA)
Wang, Huaquan…[et al.]. Recombinant Human Thrombopoietin Treatment Promotes Hematopoiesis Recovery in Patients with Severe Aplastic Anemia Receiving Immunosuppressive Therapy. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056070
American Medical Association (AMA)
Wang, Huaquan& Dong, Qi’e& Fu, Rong& Qu, Wen& Ruan, Erbao& Wang, Guojin…[et al.]. Recombinant Human Thrombopoietin Treatment Promotes Hematopoiesis Recovery in Patients with Severe Aplastic Anemia Receiving Immunosuppressive Therapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056070