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State of the Art on the Evidence Base in Cardiac Regenerative Therapy: Overview of 41 Systematic Reviews
المؤلفون المشاركون
De Falco, Elena
Chimenti, Isotta
Peruzzi, Mariangela
Lotrionte, Marzia
Marullo, Antonino G. M.
Abbate, Antonio
Frati, G.
Benedetto, Umberto
Biondi-Zoccai, Giuseppe
Delewi, Ronak
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
To provide a comprehensive appraisal of the evidence from secondary research on cardiac regenerative therapy.
Study Design and Setting.
Overview of systematic reviews of controlled clinical trials concerning stem cell administration or mobilization in patients with cardiovascular disease.
Results.
After a systematic database search, we short-listed 41 reviews (660 patients).
Twenty-two (54%) reviews focused on acute myocardial infarction (AMI), 19 (46%) on chronic ischemic heart disease (IHD) or heart failure (HF), 29 (71%) on bone marrow-derived stem-cells (BMSC), and 36 (88%) to randomized trials only.
Substantial variability among reviews was found for validity (AMSTAR score: median 9 [minimum 3]; 1st quartile 9; 3rd quartile 10; maximum 11), effect estimates (change in ejection fraction from baseline to follow-up: 3.47% [0.02%; 2.90%; 4.22%; 6.11%]), and citations (Web of Science yearly citations: 4.1 [0; 2.2; 6.5; 68.9]).
No significant association was found between these three features.
However, reviews focusing on BMSC therapy had higher validity scores ( P = 0.008 ) and showed more pronounced effect estimates ( P = 0.002 ).
Higher citations were associated with journal impact factor ( P = 0.007 ), corresponding author from North America/Europe ( P = 0.022 ), and inclusion of nonrandomized trials ( P = 0.046 ).
Conclusions.
Substantial heterogeneity is apparent among these reviews in terms of quality and effect estimates.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peruzzi, Mariangela& De Falco, Elena& Abbate, Antonio& Biondi-Zoccai, Giuseppe& Chimenti, Isotta& Lotrionte, Marzia…[et al.]. 2015. State of the Art on the Evidence Base in Cardiac Regenerative Therapy: Overview of 41 Systematic Reviews. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056127
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peruzzi, Mariangela…[et al.]. State of the Art on the Evidence Base in Cardiac Regenerative Therapy: Overview of 41 Systematic Reviews. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056127
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peruzzi, Mariangela& De Falco, Elena& Abbate, Antonio& Biondi-Zoccai, Giuseppe& Chimenti, Isotta& Lotrionte, Marzia…[et al.]. State of the Art on the Evidence Base in Cardiac Regenerative Therapy: Overview of 41 Systematic Reviews. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056127
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056127
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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