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State of the Art on the Evidence Base in Cardiac Regenerative Therapy: Overview of 41 Systematic Reviews
Joint Authors
De Falco, Elena
Chimenti, Isotta
Peruzzi, Mariangela
Lotrionte, Marzia
Marullo, Antonino G. M.
Abbate, Antonio
Frati, G.
Benedetto, Umberto
Biondi-Zoccai, Giuseppe
Delewi, Ronak
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To provide a comprehensive appraisal of the evidence from secondary research on cardiac regenerative therapy.
Study Design and Setting.
Overview of systematic reviews of controlled clinical trials concerning stem cell administration or mobilization in patients with cardiovascular disease.
Results.
After a systematic database search, we short-listed 41 reviews (660 patients).
Twenty-two (54%) reviews focused on acute myocardial infarction (AMI), 19 (46%) on chronic ischemic heart disease (IHD) or heart failure (HF), 29 (71%) on bone marrow-derived stem-cells (BMSC), and 36 (88%) to randomized trials only.
Substantial variability among reviews was found for validity (AMSTAR score: median 9 [minimum 3]; 1st quartile 9; 3rd quartile 10; maximum 11), effect estimates (change in ejection fraction from baseline to follow-up: 3.47% [0.02%; 2.90%; 4.22%; 6.11%]), and citations (Web of Science yearly citations: 4.1 [0; 2.2; 6.5; 68.9]).
No significant association was found between these three features.
However, reviews focusing on BMSC therapy had higher validity scores ( P = 0.008 ) and showed more pronounced effect estimates ( P = 0.002 ).
Higher citations were associated with journal impact factor ( P = 0.007 ), corresponding author from North America/Europe ( P = 0.022 ), and inclusion of nonrandomized trials ( P = 0.046 ).
Conclusions.
Substantial heterogeneity is apparent among these reviews in terms of quality and effect estimates.
American Psychological Association (APA)
Peruzzi, Mariangela& De Falco, Elena& Abbate, Antonio& Biondi-Zoccai, Giuseppe& Chimenti, Isotta& Lotrionte, Marzia…[et al.]. 2015. State of the Art on the Evidence Base in Cardiac Regenerative Therapy: Overview of 41 Systematic Reviews. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056127
Modern Language Association (MLA)
Peruzzi, Mariangela…[et al.]. State of the Art on the Evidence Base in Cardiac Regenerative Therapy: Overview of 41 Systematic Reviews. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056127
American Medical Association (AMA)
Peruzzi, Mariangela& De Falco, Elena& Abbate, Antonio& Biondi-Zoccai, Giuseppe& Chimenti, Isotta& Lotrionte, Marzia…[et al.]. State of the Art on the Evidence Base in Cardiac Regenerative Therapy: Overview of 41 Systematic Reviews. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056127