Temozolomide and Radiotherapy versus Radiotherapy Alone in High Grade Gliomas: A Very Long Term Comparative Study and Literature Review
المؤلفون المشاركون
Corsa, Pietro
Raguso, Arcangela
Perrone, Antonio
Cossa, Sabrina
Munafò, Tindara
Sanpaolo, Gerardo
Donno, Elisa
Clemente, Maria Antonietta
Piombino, Michele
Parisi, Federico
Parisi, Salvatore
Valle, Guido
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Temozolomide (TMZ) is the first line drug in the care of high grade gliomas.
The combined treatment of TMZ plus radiotherapy is more effective in the care of brain gliomas then radiotherapy alone.
Aim of this report is a survival comparison, on a long time (>10 years) span, of glioma patients treated with radiotherapy alone and with radiotherapy + TMZ.
Materials and Methods.
In this report we retrospectively reviewed the outcome of 128 consecutive pts with diagnosis of high grade gliomas referred to our institutions from April 1994 to November 2001.
The first 64 pts were treated with RT alone and the other 64 with a combination of RT and adjuvant or concomitant TMZ.
Results.
Grade 3 (G3) haematological toxicity was recorded in 6 (9%) of 64 pts treated with RT and TMZ.
No G4 haematological toxicity was observed.
Age, histology, and administration of TMZ were statistically significant prognostic factors associated with 2 years overall survival (OS).
PFS was for GBM 9 months, for AA 11.
Conclusions.
The combination of RT and TMZ improves long term survival in glioma patients.
Our results confirm the superiority of the combination on a long time basis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Parisi, Salvatore& Corsa, Pietro& Raguso, Arcangela& Perrone, Antonio& Cossa, Sabrina& Munafò, Tindara…[et al.]. 2015. Temozolomide and Radiotherapy versus Radiotherapy Alone in High Grade Gliomas: A Very Long Term Comparative Study and Literature Review. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056156
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Parisi, Salvatore…[et al.]. Temozolomide and Radiotherapy versus Radiotherapy Alone in High Grade Gliomas: A Very Long Term Comparative Study and Literature Review. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056156
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Parisi, Salvatore& Corsa, Pietro& Raguso, Arcangela& Perrone, Antonio& Cossa, Sabrina& Munafò, Tindara…[et al.]. Temozolomide and Radiotherapy versus Radiotherapy Alone in High Grade Gliomas: A Very Long Term Comparative Study and Literature Review. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056156
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056156
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر