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Temozolomide and Radiotherapy versus Radiotherapy Alone in High Grade Gliomas: A Very Long Term Comparative Study and Literature Review
Joint Authors
Corsa, Pietro
Raguso, Arcangela
Perrone, Antonio
Cossa, Sabrina
Munafò, Tindara
Sanpaolo, Gerardo
Donno, Elisa
Clemente, Maria Antonietta
Piombino, Michele
Parisi, Federico
Parisi, Salvatore
Valle, Guido
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Temozolomide (TMZ) is the first line drug in the care of high grade gliomas.
The combined treatment of TMZ plus radiotherapy is more effective in the care of brain gliomas then radiotherapy alone.
Aim of this report is a survival comparison, on a long time (>10 years) span, of glioma patients treated with radiotherapy alone and with radiotherapy + TMZ.
Materials and Methods.
In this report we retrospectively reviewed the outcome of 128 consecutive pts with diagnosis of high grade gliomas referred to our institutions from April 1994 to November 2001.
The first 64 pts were treated with RT alone and the other 64 with a combination of RT and adjuvant or concomitant TMZ.
Results.
Grade 3 (G3) haematological toxicity was recorded in 6 (9%) of 64 pts treated with RT and TMZ.
No G4 haematological toxicity was observed.
Age, histology, and administration of TMZ were statistically significant prognostic factors associated with 2 years overall survival (OS).
PFS was for GBM 9 months, for AA 11.
Conclusions.
The combination of RT and TMZ improves long term survival in glioma patients.
Our results confirm the superiority of the combination on a long time basis.
American Psychological Association (APA)
Parisi, Salvatore& Corsa, Pietro& Raguso, Arcangela& Perrone, Antonio& Cossa, Sabrina& Munafò, Tindara…[et al.]. 2015. Temozolomide and Radiotherapy versus Radiotherapy Alone in High Grade Gliomas: A Very Long Term Comparative Study and Literature Review. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056156
Modern Language Association (MLA)
Parisi, Salvatore…[et al.]. Temozolomide and Radiotherapy versus Radiotherapy Alone in High Grade Gliomas: A Very Long Term Comparative Study and Literature Review. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056156
American Medical Association (AMA)
Parisi, Salvatore& Corsa, Pietro& Raguso, Arcangela& Perrone, Antonio& Cossa, Sabrina& Munafò, Tindara…[et al.]. Temozolomide and Radiotherapy versus Radiotherapy Alone in High Grade Gliomas: A Very Long Term Comparative Study and Literature Review. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056156