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Correlation of Serum Levels of Endostatin with Tumor Stage in Gastric Cancer: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Wang, Zheng-Hua
Zhu, Zhi-Tu
Xiao, Xu-Yang
Sun, Jin
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
We performed a systematic review and meta-analysis to study the association between serum endostatin levels and gastric cancer (GC) progression.
Method.
We searched the MEDLINE, Science Citation Index, Cochrane Library, PubMed, Embase, Current Contents Index, and several Chinese databases for published studies relevant to our study topic.
Carefully selected studies were pooled and SMD and its corresponding 95% CI were calculated.
Version 12.0 STATA software was used for statistical analysis.
Results.
Serum endostatin levels were analyzed in 12 case-control studies (736 GC patients and 350 controls).
Significant differences in serum endostatin levels were observed between GC patients and the healthy controls (SMD = 1.418, 95% CI = 1.079~1.757, P < 0 .
001 ).
Importantly, significantly lower levels of serum endostatin were found in I-II grade patients compared to those with III-IV grade tumors ( P < 0 .
001 ).
Further, higher serum endostatin levels were observed in the LN invasion-positive GC subjects in comparison with LN invasion-negative subjects ( P < 0 .
001 ).
Conclusion.
Patients with GC exhibited elevated levels of serum endostatin than controls and its level showed a statistical correlation with the more aggressive type of GC, exhibiting invasion and LN metastasis.
Thus, serum levels of endostatin being a useful prognostic biomarker for GC patients warrants further investigation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Zheng-Hua& Zhu, Zhi-Tu& Xiao, Xu-Yang& Sun, Jin. 2015. Correlation of Serum Levels of Endostatin with Tumor Stage in Gastric Cancer: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056170
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Zheng-Hua…[et al.]. Correlation of Serum Levels of Endostatin with Tumor Stage in Gastric Cancer: A Systematic Review and Meta-Analysis. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056170
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Zheng-Hua& Zhu, Zhi-Tu& Xiao, Xu-Yang& Sun, Jin. Correlation of Serum Levels of Endostatin with Tumor Stage in Gastric Cancer: A Systematic Review and Meta-Analysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056170
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056170
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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