Correlation of Serum Levels of Endostatin with Tumor Stage in Gastric Cancer: A Systematic Review and Meta-Analysis
Joint Authors
Wang, Zheng-Hua
Zhu, Zhi-Tu
Xiao, Xu-Yang
Sun, Jin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
We performed a systematic review and meta-analysis to study the association between serum endostatin levels and gastric cancer (GC) progression.
Method.
We searched the MEDLINE, Science Citation Index, Cochrane Library, PubMed, Embase, Current Contents Index, and several Chinese databases for published studies relevant to our study topic.
Carefully selected studies were pooled and SMD and its corresponding 95% CI were calculated.
Version 12.0 STATA software was used for statistical analysis.
Results.
Serum endostatin levels were analyzed in 12 case-control studies (736 GC patients and 350 controls).
Significant differences in serum endostatin levels were observed between GC patients and the healthy controls (SMD = 1.418, 95% CI = 1.079~1.757, P < 0 .
001 ).
Importantly, significantly lower levels of serum endostatin were found in I-II grade patients compared to those with III-IV grade tumors ( P < 0 .
001 ).
Further, higher serum endostatin levels were observed in the LN invasion-positive GC subjects in comparison with LN invasion-negative subjects ( P < 0 .
001 ).
Conclusion.
Patients with GC exhibited elevated levels of serum endostatin than controls and its level showed a statistical correlation with the more aggressive type of GC, exhibiting invasion and LN metastasis.
Thus, serum levels of endostatin being a useful prognostic biomarker for GC patients warrants further investigation.
American Psychological Association (APA)
Wang, Zheng-Hua& Zhu, Zhi-Tu& Xiao, Xu-Yang& Sun, Jin. 2015. Correlation of Serum Levels of Endostatin with Tumor Stage in Gastric Cancer: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056170
Modern Language Association (MLA)
Wang, Zheng-Hua…[et al.]. Correlation of Serum Levels of Endostatin with Tumor Stage in Gastric Cancer: A Systematic Review and Meta-Analysis. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056170
American Medical Association (AMA)
Wang, Zheng-Hua& Zhu, Zhi-Tu& Xiao, Xu-Yang& Sun, Jin. Correlation of Serum Levels of Endostatin with Tumor Stage in Gastric Cancer: A Systematic Review and Meta-Analysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056170