Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis
المؤلفون المشاركون
Wei, Hengxi
Liu, Xiangjie
Yuan, Jihong
Li, Li
Zhang, Dongdong
Guo, Xinzheng
Liu, Lin
Zhang, Shouquan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-02
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The biological function of human ovaries declines with age.
To identify the potential molecular changes in ovarian aging, we performed genome-wide gene expression analysis by microarray of ovaries from young, middle-aged, and old rhesus monkeys.
Microarray data was validated by quantitative real-time PCR.
Results showed that a total of 503 (60 upregulated, 443 downregulated) and 84 (downregulated) genes were differentially expressed in old ovaries compared to young and middle-aged groups, respectively.
No difference in gene expression was found between middle-aged and young groups.
Differentially expressed genes were mainly enriched in cell and organelle, cellular and physiological process, binding, and catalytic activity.
These genes were primarily associated with KEGG pathways of cell cycle, DNA replication and repair, oocyte meiosis and maturation, MAPK, TGF-beta, and p53 signaling pathway.
Genes upregulated were involved in aging, defense response, oxidation reduction, and negative regulation of cellular process; genes downregulated have functions in reproduction, cell cycle, DNA and RNA process, macromolecular complex assembly, and positive regulation of macromolecule metabolic process.
These findings show that monkey ovary undergoes substantial change in global transcription with age.
Gene expression profiles are useful in understanding the mechanisms underlying ovarian aging and age-associated infertility in primates.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wei, Hengxi& Liu, Xiangjie& Yuan, Jihong& Li, Li& Zhang, Dongdong& Guo, Xinzheng…[et al.]. 2015. Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056178
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wei, Hengxi…[et al.]. Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1056178
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wei, Hengxi& Liu, Xiangjie& Yuan, Jihong& Li, Li& Zhang, Dongdong& Guo, Xinzheng…[et al.]. Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056178
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056178
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر