![](/images/graphics-bg.png)
Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis
Joint Authors
Wei, Hengxi
Liu, Xiangjie
Yuan, Jihong
Li, Li
Zhang, Dongdong
Guo, Xinzheng
Liu, Lin
Zhang, Shouquan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-02
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The biological function of human ovaries declines with age.
To identify the potential molecular changes in ovarian aging, we performed genome-wide gene expression analysis by microarray of ovaries from young, middle-aged, and old rhesus monkeys.
Microarray data was validated by quantitative real-time PCR.
Results showed that a total of 503 (60 upregulated, 443 downregulated) and 84 (downregulated) genes were differentially expressed in old ovaries compared to young and middle-aged groups, respectively.
No difference in gene expression was found between middle-aged and young groups.
Differentially expressed genes were mainly enriched in cell and organelle, cellular and physiological process, binding, and catalytic activity.
These genes were primarily associated with KEGG pathways of cell cycle, DNA replication and repair, oocyte meiosis and maturation, MAPK, TGF-beta, and p53 signaling pathway.
Genes upregulated were involved in aging, defense response, oxidation reduction, and negative regulation of cellular process; genes downregulated have functions in reproduction, cell cycle, DNA and RNA process, macromolecular complex assembly, and positive regulation of macromolecule metabolic process.
These findings show that monkey ovary undergoes substantial change in global transcription with age.
Gene expression profiles are useful in understanding the mechanisms underlying ovarian aging and age-associated infertility in primates.
American Psychological Association (APA)
Wei, Hengxi& Liu, Xiangjie& Yuan, Jihong& Li, Li& Zhang, Dongdong& Guo, Xinzheng…[et al.]. 2015. Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056178
Modern Language Association (MLA)
Wei, Hengxi…[et al.]. Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1056178
American Medical Association (AMA)
Wei, Hengxi& Liu, Xiangjie& Yuan, Jihong& Li, Li& Zhang, Dongdong& Guo, Xinzheng…[et al.]. Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056178