Transferrin: Endocytosis and Cell Signaling in Parasitic Protozoa

المؤلفون المشاركون

Reyes-López, Magda
Serrano-Luna, Jesús
Piña-Vázquez, Carolina

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-05-18

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الطب البشري

الملخص EN

Iron is the fourth most abundant element on Earth and the most abundant metal in the human body.

This element is crucial for life because almost all organisms need iron for several biological activities.

This is the case with pathogenic organisms, which are at the vanguard in the battle with the human host for iron.

The latest regulates Fe concentration through several iron-containing proteins, such as transferrin.

The transferrin receptor transports iron to each cell that needs it and maintains it away from pathogens.

Parasites have developed several strategies to obtain iron as the expression of specific transferrin receptors localized on plasma membrane, internalized through endocytosis.

Signal transduction pathways related to the activation of the receptor have functional importance in proliferation.

The study of transferrin receptors and other proteins with action in the signaling networks is important because these proteins could be used as therapeutic targets due to their specificity or to differences with the human counterpart.

In this work, we describe proteins that participate in signal transduction processes, especially those that involve transferrin endocytosis, and we compare these processes with those found in T.

brucei, T.

cruzi, Leishmania spp., and E.

histolytica parasites.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Reyes-López, Magda& Piña-Vázquez, Carolina& Serrano-Luna, Jesús. 2015. Transferrin: Endocytosis and Cell Signaling in Parasitic Protozoa. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056246

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Reyes-López, Magda…[et al.]. Transferrin: Endocytosis and Cell Signaling in Parasitic Protozoa. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056246

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Reyes-López, Magda& Piña-Vázquez, Carolina& Serrano-Luna, Jesús. Transferrin: Endocytosis and Cell Signaling in Parasitic Protozoa. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056246

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1056246