Transferrin: Endocytosis and Cell Signaling in Parasitic Protozoa
Joint Authors
Reyes-López, Magda
Serrano-Luna, Jesús
Piña-Vázquez, Carolina
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Iron is the fourth most abundant element on Earth and the most abundant metal in the human body.
This element is crucial for life because almost all organisms need iron for several biological activities.
This is the case with pathogenic organisms, which are at the vanguard in the battle with the human host for iron.
The latest regulates Fe concentration through several iron-containing proteins, such as transferrin.
The transferrin receptor transports iron to each cell that needs it and maintains it away from pathogens.
Parasites have developed several strategies to obtain iron as the expression of specific transferrin receptors localized on plasma membrane, internalized through endocytosis.
Signal transduction pathways related to the activation of the receptor have functional importance in proliferation.
The study of transferrin receptors and other proteins with action in the signaling networks is important because these proteins could be used as therapeutic targets due to their specificity or to differences with the human counterpart.
In this work, we describe proteins that participate in signal transduction processes, especially those that involve transferrin endocytosis, and we compare these processes with those found in T.
brucei, T.
cruzi, Leishmania spp., and E.
histolytica parasites.
American Psychological Association (APA)
Reyes-López, Magda& Piña-Vázquez, Carolina& Serrano-Luna, Jesús. 2015. Transferrin: Endocytosis and Cell Signaling in Parasitic Protozoa. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056246
Modern Language Association (MLA)
Reyes-López, Magda…[et al.]. Transferrin: Endocytosis and Cell Signaling in Parasitic Protozoa. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056246
American Medical Association (AMA)
Reyes-López, Magda& Piña-Vázquez, Carolina& Serrano-Luna, Jesús. Transferrin: Endocytosis and Cell Signaling in Parasitic Protozoa. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056246