The Application of Fluorescence Optical Imaging in Systemic Sclerosis
المؤلفون المشاركون
Jung, Christian
Pfeil, Alexander
Drummer, Karl F.
Böttcher, Joachim
Oelzner, Peter
Renz, Diane M.
Hansch, Andreas
Wolf, Gunter
Franz, Marcus
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
The aim of this study was to visualize soft tissue inflammation using FOI on patients with Systemic Sclerosis (SSc) characterized by SSc-related Raynaud’s phenomenon and to detect the therapeutic response to treatment with iloprost or alprostadil.
Methods.
Twenty-one patients with SSc and Raynaud’s phenomenon and twenty-six healthy controls were prospectively included.
The SSc patients were intravenously treated with iloprost or alprostadil over seven days.
FOI was performed at baseline and after seven days using an intravenous application of indocyanine green (ICG).
The hands were divided into nineteen segments per hand.
All segments were quantitatively evaluated to determine changes in ICG.
Results.
The sensitivity and specificity of FOI in the detection of ICG enhancement in patients with SSc were 95% versus 96%.
At baseline, 31.5% hand segments showed ICG enhancement.
After seven days of either iloprost or alprostadil therapy a significant reduction in the ICG was observed which ranged from 40.9% to 24.7%.
Conclusion.
The study demonstrates that the FOI technique is able to visualize soft-tissue inflammation with both high sensitivity and specificity.
The anti-inflammatory therapeutic effects of iloprost were slightly stronger than alprostadil.
FOI offers promising benefits in the diagnosis and therapy of patients with SSc-associated Raynaud’s phenomenon.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pfeil, Alexander& Drummer, Karl F.& Böttcher, Joachim& Jung, Christian& Oelzner, Peter& Renz, Diane M.…[et al.]. 2015. The Application of Fluorescence Optical Imaging in Systemic Sclerosis. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056318
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pfeil, Alexander…[et al.]. The Application of Fluorescence Optical Imaging in Systemic Sclerosis. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056318
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pfeil, Alexander& Drummer, Karl F.& Böttcher, Joachim& Jung, Christian& Oelzner, Peter& Renz, Diane M.…[et al.]. The Application of Fluorescence Optical Imaging in Systemic Sclerosis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056318
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056318
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر