The Application of Fluorescence Optical Imaging in Systemic Sclerosis

Joint Authors

Jung, Christian
Pfeil, Alexander
Drummer, Karl F.
Böttcher, Joachim
Oelzner, Peter
Renz, Diane M.
Hansch, Andreas
Wolf, Gunter
Franz, Marcus

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-08-18

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Medicine

Abstract EN

Objective.

The aim of this study was to visualize soft tissue inflammation using FOI on patients with Systemic Sclerosis (SSc) characterized by SSc-related Raynaud’s phenomenon and to detect the therapeutic response to treatment with iloprost or alprostadil.

Methods.

Twenty-one patients with SSc and Raynaud’s phenomenon and twenty-six healthy controls were prospectively included.

The SSc patients were intravenously treated with iloprost or alprostadil over seven days.

FOI was performed at baseline and after seven days using an intravenous application of indocyanine green (ICG).

The hands were divided into nineteen segments per hand.

All segments were quantitatively evaluated to determine changes in ICG.

Results.

The sensitivity and specificity of FOI in the detection of ICG enhancement in patients with SSc were 95% versus 96%.

At baseline, 31.5% hand segments showed ICG enhancement.

After seven days of either iloprost or alprostadil therapy a significant reduction in the ICG was observed which ranged from 40.9% to 24.7%.

Conclusion.

The study demonstrates that the FOI technique is able to visualize soft-tissue inflammation with both high sensitivity and specificity.

The anti-inflammatory therapeutic effects of iloprost were slightly stronger than alprostadil.

FOI offers promising benefits in the diagnosis and therapy of patients with SSc-associated Raynaud’s phenomenon.

American Psychological Association (APA)

Pfeil, Alexander& Drummer, Karl F.& Böttcher, Joachim& Jung, Christian& Oelzner, Peter& Renz, Diane M.…[et al.]. 2015. The Application of Fluorescence Optical Imaging in Systemic Sclerosis. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056318

Modern Language Association (MLA)

Pfeil, Alexander…[et al.]. The Application of Fluorescence Optical Imaging in Systemic Sclerosis. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056318

American Medical Association (AMA)

Pfeil, Alexander& Drummer, Karl F.& Böttcher, Joachim& Jung, Christian& Oelzner, Peter& Renz, Diane M.…[et al.]. The Application of Fluorescence Optical Imaging in Systemic Sclerosis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056318

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1056318