Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis?
المؤلفون المشاركون
Södergren, Anna
Karp, Kjell
Bengtsson, Christine
Möller, Bozena
Rantapää-Dahlqvist, Solbritt
Wållberg-Jonsson, Solveig
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease.
This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis (RA).
Methods.
Patients from northern Sweden diagnosed with early RA were consecutively recruited into an ongoing prospective study.
From these, all patients ≤60 years ( n = 71 ) were included for measurements of subclinical atherosclerosis at inclusion (T0) and five years later (T5).
Forty age- and sex-matched controls were included.
The patients were clinically assessed, SCORE, Reynolds Risk Score, and Larsen score were calculated, and blood samples were drawn from all individuals at T0 and T5.
Results.
There was no significant difference in the level of Lp-PLA2 between patients with RA and controls ( p > 0.05 ).
In simple linear regression models among patients with RA, Lp-PLA2 at T0 was significantly associated with intima media thickness (IMT) at T0 and T5, flow mediated dilation (FMD) at T0 and T5, ever smoking, male sex, HDL-cholesterol (inversely), non-HDL-cholesterol, SCORE, Reynolds Risk Score, and Larsen score ( p < 0.05 ).
Conclusion.
In this cohort of patients with early RA, the concentration of Lp-PLA2 was associated with both subclinical atherosclerosis and disease severity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Södergren, Anna& Karp, Kjell& Bengtsson, Christine& Möller, Bozena& Rantapää-Dahlqvist, Solbritt& Wållberg-Jonsson, Solveig. 2015. Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis?. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056339
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Södergren, Anna…[et al.]. Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis?. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056339
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Södergren, Anna& Karp, Kjell& Bengtsson, Christine& Möller, Bozena& Rantapää-Dahlqvist, Solbritt& Wållberg-Jonsson, Solveig. Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis?. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056339
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056339
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر